Young R E
J Med. 1979;10(6):417-28.
One hundred four patients with moderate to severe postoperative pain participated in a double-blind study comparing butorphanol/acetaminophen with oxycodone/acetaminophen and placebo with respect to analgesic effectiveness and incidence of side effects. Pain was rated by the patients and an observer; sums of these data were calculated. Side effects, their severity and their relationship to the drug were recorded. Both active medications provided statistically significant levels of analgesia as compared with placebo. Analgesia produced by both combinations of drugs was statistically similar until 4 hours postdrug. From 4 to 6 hours postdrug, butorphanol/acetaminophen was significantly more analgesic. Both active medications produced analgesia within 0.5 hours, showing a peak effect at 1 to 2 hours and lasting for 6 hours. The incidence of side effects was minimal and statistically equivalent for each treatment group.
104例中重度术后疼痛患者参与了一项双盲研究，比较了布托啡诺/对乙酰氨基酚、羟考酮/对乙酰氨基酚和安慰剂在镇痛效果及副作用发生率方面的差异。患者和一名观察者对疼痛进行评分，并计算这些数据的总和。记录副作用、其严重程度及其与药物的关系。与安慰剂相比，两种活性药物均提供了具有统计学意义的镇痛水平。两种药物组合产生的镇痛效果在用药后4小时内统计学上相似。用药后4至6小时，布托啡诺/对乙酰氨基酚的镇痛效果明显更强。两种活性药物均在0.5小时内产生镇痛作用，在1至2小时达到峰值效应，并持续6小时。每个治疗组的副作用发生率极低且在统计学上相当。
