Department of Gastroenterology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China.
Inflamm Bowel Dis. 2018 Aug 16;24(9):1883-1894. doi: 10.1093/ibd/izy221.
Ulcerative colitis (UC) is an independent risk factor of colorectal cancer (CRC). Both genetic and epigentic events induce a unique molecular profile during the development from UC to UC-related CRC (UCRC). These molecular changes play varied roles in DNA repair, immune response, cell metabolism, and interaction with the microbiota during the carcinogenesis process. This review will systmatically discuss the molecular characteristics of UCRC and point out the future perspectives in this research field.
溃疡性结肠炎（UC）是结直肠癌（CRC）的独立危险因素。在从 UC 发展到 UC 相关 CRC（UCRC）的过程中，遗传和表观遗传事件会诱导出独特的分子谱。这些分子变化在癌变过程中在 DNA 修复、免疫反应、细胞代谢以及与微生物组的相互作用中发挥了不同的作用。本综述将系统地讨论 UCRC 的分子特征，并指出该研究领域的未来展望。
