Lee K O, Chan H L, Lee H L
Ann Acad Med Singap. 1985 Apr;14(2):312-6.
The glucagonoma syndrome is a rare clinical condition. In this syndrome there is a pancreatic islet cell tumour which secretes glucagon, associated with a distinctive skin eruption--migratory necrolytic erythema. We describe a 79 year old Chinese man who presented with the typical skin features of this condition and on investigation had a pancreatic islet cell tumour. Serum glucagon levels were markedly elevated. He had a partial pancreatectomy and the skin rash improved dramatically. However he had liver metastases and responded poorly to streptozotocin. The skin features recurred and the patient died 9 months after diagnosis. As far as we are aware, this is the first report of a Glucagonoma syndrome in a Chinese.
胰高血糖素瘤综合征是一种罕见的临床病症。在该综合征中，存在一种分泌胰高血糖素的胰岛细胞瘤，并伴有独特的皮肤疹——游走性坏死性红斑。我们描述了一名79岁的中国男性，他表现出该病症的典型皮肤特征，经检查发现患有胰岛细胞瘤。血清胰高血糖素水平显著升高。他接受了部分胰腺切除术，皮疹明显改善。然而，他出现了肝转移，对链脲佐菌素反应不佳。皮肤特征复发，患者在诊断后9个月死亡。据我们所知，这是关于中国人患胰高血糖素瘤综合征的首例报告。
