Ghosh S N, Seshadri R, Banerji A P, Sampat M B
Anticancer Res. 1985 Jul-Aug;5(4):445-9.
Prediction of early metastases in individual patients has been attempted by combined evaluation of a battery of recognised parameters such as blood vessel invasion (BVI) of tumor cells, Barr body frequency (BBF), plasminogen activator (PA), collagenase, estradiol receptors (ER), progesterone receptors (PgR), and peroxidase activity (PRA) in 18 malignant and 3 benign (control) breast tumors. Since breast tumor cells spread through the blood vessels, the cases were divided into BVI (+) and BVI (-) groups. Results show that in the former group, all the cases had poor prognosis and two even had distant metastases within one year. In BVI (-) group, 9 out of 12 appeared to have good prognosis.
通过综合评估一系列公认的参数，如18例恶性乳腺肿瘤和3例良性（对照）乳腺肿瘤中的肿瘤细胞血管侵犯（BVI）、巴氏小体频率（BBF）、纤溶酶原激活物（PA）、胶原酶、雌二醇受体（ER）、孕酮受体（PgR）和过氧化物酶活性（PRA），尝试对个体患者的早期转移进行预测。由于乳腺肿瘤细胞通过血管扩散，病例被分为BVI（+）组和BVI（-）组。结果显示，在前一组中，所有病例预后均较差，其中两例甚至在一年内发生了远处转移。在BVI（-）组中，12例中有9例似乎预后良好。
