Chadwick D R, Corbett K, Mann S, Teruzzi B, Horner S
Centre for Clinical Infection, James Cook University Hospital, Middlesbrough, UK.
Int J STD AIDS. 2018 Oct;29(12):1190-1193. doi: 10.1177/0956462418779472. Epub 2018 Jun 26.
An increased risk of vaccine-preventable infections (VPIs) is seen in people living with HIV (PLWH), and current vaccine coverage and immunity is variable. Vaccine passports have the potential to improve vaccine coverage. The objective was to assess how successful a vaccine passport was in improving vaccine coverage in PLWH. Baseline immunity to VPIs was established in PLWH attending a single HIV clinic and vaccinations required were determined based on the BHIVA Vaccination Guidelines (2015). The passport was completed and the PLWH informed about additional vaccines they should obtain from primary care. After 6-9 months the passport was reviewed including confirmation if vaccines were given. PLWH satisfaction with the system was evaluated by a survey. Seventy-three PLWH provided sufficient data for analysis. At baseline significant proportions of PLWH were not immune/unvaccinated to the main VPIs, especially human papillomavirus, pneumococcus and measles. After the passport was applied immunity improved significantly (56% overall, p < 0.01) for most VPIs; however, full coverage was not achieved. The system was popular with PLWH. The passport was successful in increasing vaccination coverage although full or near-full coverage was not achieved. A more successful service would probably be achieved by commissioning English HIV clinics to provide all vaccines.
艾滋病毒感染者（PLWH）出现疫苗可预防感染（VPI）的风险增加，且目前的疫苗接种覆盖率和免疫力存在差异。疫苗护照有提高疫苗接种覆盖率的潜力。目的是评估疫苗护照在提高PLWH疫苗接种覆盖率方面的成效。在一家单一的艾滋病毒诊所就诊的PLWH中确定了对VPI的基线免疫力，并根据英国艾滋病毒协会疫苗接种指南（2015年）确定所需的疫苗接种。填写了护照，并告知PLWH他们应从初级保健机构获取的其他疫苗。6至9个月后，对护照进行了审查，包括确认是否已接种疫苗。通过一项调查评估了PLWH对该系统的满意度。73名PLWH提供了足够的数据分析。在基线时，相当比例的PLWH对主要的VPI没有免疫力/未接种疫苗，尤其是人乳头瘤病毒、肺炎球菌和麻疹。应用护照后，大多数VPI的免疫力显著提高（总体为56%，p<0.01）；然而，并未实现完全覆盖。该系统受到PLWH的欢迎。尽管未实现完全或接近完全覆盖，但护照在提高疫苗接种覆盖率方面是成功的。委托英国艾滋病毒诊所提供所有疫苗可能会实现更成功的服务。
