Feline calicivirus subunit vaccine--a prototype.

A vaccine was prepared from a subunit component, antigenically similar to the whole feline calicivirus (FCV) particles. Despite the limited number of animals available for this study we were able to demonstrate that the vaccine protected cats when challenged with a virulent strain of the virus while the non-vaccinates kept as controls developed clinical and histopathological symptoms of the calicivirus disease.