Furuse K
Gan To Kagaku Ryoho. 1985 Sep;12(9):1844-9.
From April 1981 to February 1983, 116 untreated patients (ECOG PS 0-3) with histologically or cytologically proven small cell lung cancer were randomly allocated to chemotherapy regimen using CPA.ACNU.VCR (CNV, n = 64) or ADR.ACNU.VCR (ANV, n = 52). The objective tumor response was 29.7% (19/53) for the CNV regimen and 48.1% (25/48) for the ANV regimen, but there was no statistically significant difference in these groups. Median survival time was 22.9 w for the CNV regimen (n = 64) and 42.4 w for the ANV (n = 52) regimen. The survival rate was statistically significantly higher for the ANV regimen compared to that of the CNV regimen (P greater than 5%). The toxicity showed no difference between these groups. Addition of ADR to ACNU + VCR was effective, but addition of CPA to these two drugs was not effective.
1981年4月至1983年2月，116例未经治疗的组织学或细胞学确诊的小细胞肺癌患者（东部肿瘤协作组体能状态0 - 3级）被随机分配至使用环磷酰胺、阿糖胞苷、长春新碱（CNV，n = 64）或阿霉素、阿糖胞苷、长春新碱（ANV，n = 52）的化疗方案。CNV方案的客观肿瘤缓解率为29.7%（19/53），ANV方案为48.1%（25/48），但两组间无统计学显著差异。CNV方案（n = 64）的中位生存时间为22.9周，ANV方案（n = 52）为42.4周。与CNV方案相比，ANV方案的生存率在统计学上显著更高（P大于5%）。两组间毒性无差异。在阿糖胞苷 + 长春新碱基础上加用阿霉素有效，但在这两种药物基础上加用环磷酰胺无效。
