Duchatsch Francine, Constantino Paula B, Herrera Naiara A, Fabrício Mayara F, Tardelli Lidieli P, Martuscelli Aline M, Dionísio Thiago J, Santos Carlos F, Amaral Sandra L
Joint Graduate Program in Physiological Sciences, PIPGCF UFSCar/UNESP, São Carlos, SP, Brazil; Department of Physical Education, Science Faculty, UNESP - São Paulo State University, Bauru, SP, Brazil.
Department of Physical Education, Science Faculty, UNESP - São Paulo State University, Bauru, SP, Brazil.
J Am Soc Hypertens. 2018 Aug;12(8):605-613. doi: 10.1016/j.jash.2018.06.004. Epub 2018 Jun 13.
Hypertension is one of the chronic side effects of dexamethasone (DEX) treatment; however, almost nothing is known about its acute effects. Therefore, the aim of this study was to investigate the possible mechanisms involved in blood pressure control after acute or short-term DEX treatment in adult animals. Eighty Wistar rats were divided into four groups: C1 and C5, for rats treated with saline for 1 or 5 days, respectively; D1 and D5, for rats treated with DEX for 1 or 5 days, respectively (decadron, 1 mg/kg, i.p.). Heart rate was increased in DEX treatment, but arterial pressure and cardiac muscle mass were not altered. Only few and isolated changes on gene expression and protein level of renin-angiotensin system components were observed. Five days of DEX treatment, but not one day, determined an increase in sympathetic component of spectral analysis (+75.93%, P < .05) and a significant reduction of parasympathetic component (-18.02%, P < .05), which contributed to the autonomic imbalance to the heart (LF/HF, +863.69%). The results of this present study demonstrated, for the first time, that short-term exposure to DEX treatment impairs the autonomic balance to the heart before hypertension, which was independent of renin-angiotensin system.
高血压是地塞米松（DEX）治疗的慢性副作用之一；然而，关于其急性影响几乎一无所知。因此，本研究的目的是探讨成年动物急性或短期DEX治疗后血压控制的可能机制。80只Wistar大鼠分为四组：C1组和C5组，分别用生理盐水处理1天或5天；D1组和D5组，分别用DEX处理1天或5天（地塞米松，1mg/kg，腹腔注射）。DEX治疗时心率增加，但动脉血压和心肌质量未改变。仅观察到肾素-血管紧张素系统成分的基因表达和蛋白质水平有少量且孤立的变化。5天的DEX治疗而非1天的治疗，导致频谱分析中交感成分增加（+75.93%，P<0.05），副交感成分显著减少（-18.02%，P<0.05），这导致心脏自主神经失衡（低频/高频，+863.69%）。本研究结果首次表明，短期暴露于DEX治疗会在高血压发生前损害心脏的自主神经平衡，且这与肾素-血管紧张素系统无关。
