Unit and School of Geriatrics, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria n. 1, Policlinico pad B, 98125, Messina, Italy.
Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Aging Clin Exp Res. 2019 Jan;31(1):151-155. doi: 10.1007/s40520-018-0989-7. Epub 2018 Jun 26.
Frailty is a predictor of adverse outcomes in older subjects.
The aims of this study are to (1) measure the frailty status and its changes occurring during the hospital stay, (2) determine the relationships among frailty and adverse outcomes.
Frailty was assessed using a 46-item Frailty Index (FI) in 156 patients admitted to an Acute Geriatric Medicine Unit. The FI was calculated within 24 h from the hospital admission (aFI) and at his/her discharge (dFI). Patients were followed up to 12 months after the hospital discharge.
A statistically significant difference was reported between the aFI (0.31, IQR 0.19-0.44) and the dFI (0.29, IQR 0.19-0.40; p = 0.04). The aFI was directly associated with the risk of in-hospital death (OR = 5.9; 95% CI 2.0-17.5; p = 0.001), 1 year mortality (OR = 5.5, 95% CI 2.4-12.7, p < 0.001) and re-hospitalization (OR = 6.3, 95% CI 2.2-17.9, p = 0.03).
Frailty is a strong predictor of negative endpoints in hospitalized older persons.
Frailty assessment from routinely collected clinical data may provide important insights about the biological status of the individual and promote the personalization of care.
衰弱是老年患者不良结局的预测因素。
本研究旨在：（1）测量衰弱状态及其在住院期间的变化；（2）确定衰弱与不良结局之间的关系。
在入住急性老年医学科的 156 名患者中，使用 46 项衰弱指数（FI）评估衰弱。FI 在入院后 24 小时内（aFI）和出院时（dFI）计算。患者在出院后 12 个月内进行随访。
报告 aFI（0.31，IQR 0.19-0.44）和 dFI（0.29，IQR 0.19-0.40；p=0.04）之间存在统计学显著差异。aFI 与住院期间死亡风险（OR=5.9；95%CI 2.0-17.5；p=0.001）、1 年死亡率（OR=5.5，95%CI 2.4-12.7，p<0.001）和再入院（OR=6.3，95%CI 2.2-17.9，p=0.03）直接相关。
衰弱是住院老年患者负面结局的有力预测因素。
从常规收集的临床数据中评估衰弱状况可能提供有关个体生物学状况的重要见解，并促进护理的个性化。
