Lu Yueh-Hsun, Mani Karthick, Panigrahi Bivas, Hajari Saurabh, Chen Chia-Yuan
Department of Radiology, Taipei City Hospital, Zhongxing Branch, Taipei, 103, Taiwan.
Department of Radiology, Taipei Veterans General Hospital, Taipei, 112, Taiwan.
Cardiovasc Eng Technol. 2018 Sep;9(3):405-413. doi: 10.1007/s13239-018-0369-7. Epub 2018 Jun 26.
In the current scenario of endovascular intervention, surgeons have to manually navigate the catheter within the complex vasculature of the human body under the guidance of X-ray. This manual intervention upsurges the possibilities of vessel damage due to frequent contact between the catheter and vasculature wall. In this context, a shape memory alloy-based miniaturized actuator was proposed in this study with a specific aim to reduce vessel wall related damage by improving the bending motions of the guidewire tip in a semi-automatic fashion. The miniaturized actuator was integrated with a FDA-approved guidewire and tested within a patient-specific vascular network model to realize its feasibility in the real surgical environment. The results illustrate that the miniaturized actuator gives a bending angle over 23° and lateral displacement over 900 µm to the guide wire tip by which the guidewire can be navigated with precision and possible vessel damage during the catheter intervention can certainly be minimized. In addition to it, the dynamic responses of the presented actuator were further investigated through numerical simulation in conjunction with the analytic analysis.
在当前血管内介入的情况下，外科医生必须在X射线引导下在人体复杂的脉管系统中手动操控导管。这种手动干预增加了因导管与脉管壁频繁接触而导致血管损伤的可能性。在此背景下，本研究提出了一种基于形状记忆合金的微型致动器，其特定目标是以半自动方式改善导丝尖端的弯曲运动，从而减少与血管壁相关的损伤。该微型致动器与经美国食品药品监督管理局（FDA）批准的导丝集成，并在患者特异性血管网络模型中进行测试，以实现其在实际手术环境中的可行性。结果表明，该微型致动器可使导丝尖端产生超过23°的弯曲角度和超过900 µm的横向位移，通过这一方式，导丝能够被精确操控，并且在导管介入过程中可能出现的血管损伤肯定能够降至最低。除此之外，结合解析分析通过数值模拟进一步研究了所提出的致动器的动态响应。
