Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Head Neck. 2018 Sep;40(9):1881-1888. doi: 10.1002/hed.25141. Epub 2018 Jun 26.
The newly introduced pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) will result in less bilateral thyroid surgery as well as deescalation in T4 suppressive and radioactive iodine treatment. Although, NIFTP is a nonmalignant lesion that has nuclear features of some papillary malignancies, the challenge for the surgeon is to identify a lesion as possibly NIFTP before the pathologic diagnosis. NIFTP, due to its reduction of overall rates of malignancy, will result in the initial surgical pendulum swinging toward lobectomy instead of initial total thyroidectomy. This American Head and Neck Society endocrine section consensus statement is intended to inform preoperative evaluation to attempt to identify those patients whose final pathology report may ultimately harbor NIFTP and can be offered a conservative surgical plan to assist in cost-effective, optimal management of patients with NIFTP.
新引入的非侵袭性滤泡性甲状腺肿瘤伴乳头状核特征(NIFTP)的病理诊断将导致更少的双侧甲状腺手术以及 T4 抑制和放射性碘治疗的降级。尽管 NIFTP 是一种非恶性病变,具有某些甲状腺恶性肿瘤的核特征,但外科医生的挑战是在病理诊断之前识别可能为 NIFTP 的病变。由于 NIFTP 降低了总体恶性肿瘤发生率,因此初始手术将倾向于行腺叶切除术而不是初始甲状腺全切除术。美国头颈学会内分泌分会的这项共识声明旨在告知术前评估,以尝试识别那些最终病理报告可能最终存在 NIFTP 的患者,并为他们提供保守的手术计划,以协助对 NIFTP 患者进行具有成本效益的最佳管理。