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AHNS 系列:你了解你的指南吗?AHNS 内分泌科共识声明:具有滤泡状甲状腺肿瘤样核特征的非侵袭性甲状腺滤泡性肿瘤时代的甲状腺外科最新推荐。

AHNS Series: Do you know your guidelines? AHNS Endocrine Section Consensus Statement: State-of-the-art thyroid surgical recommendations in the era of noninvasive follicular thyroid neoplasm with papillary-like nuclear features.

机构信息

Department of Otolaryngology - Head and Neck Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

出版信息

Head Neck. 2018 Sep;40(9):1881-1888. doi: 10.1002/hed.25141. Epub 2018 Jun 26.

DOI:10.1002/hed.25141
PMID:29947030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6175359/
Abstract

The newly introduced pathologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) will result in less bilateral thyroid surgery as well as deescalation in T4 suppressive and radioactive iodine treatment. Although, NIFTP is a nonmalignant lesion that has nuclear features of some papillary malignancies, the challenge for the surgeon is to identify a lesion as possibly NIFTP before the pathologic diagnosis. NIFTP, due to its reduction of overall rates of malignancy, will result in the initial surgical pendulum swinging toward lobectomy instead of initial total thyroidectomy. This American Head and Neck Society endocrine section consensus statement is intended to inform preoperative evaluation to attempt to identify those patients whose final pathology report may ultimately harbor NIFTP and can be offered a conservative surgical plan to assist in cost-effective, optimal management of patients with NIFTP.

摘要

新引入的非侵袭性滤泡性甲状腺肿瘤伴乳头状核特征(NIFTP)的病理诊断将导致更少的双侧甲状腺手术以及 T4 抑制和放射性碘治疗的降级。尽管 NIFTP 是一种非恶性病变,具有某些甲状腺恶性肿瘤的核特征,但外科医生的挑战是在病理诊断之前识别可能为 NIFTP 的病变。由于 NIFTP 降低了总体恶性肿瘤发生率,因此初始手术将倾向于行腺叶切除术而不是初始甲状腺全切除术。美国头颈学会内分泌分会的这项共识声明旨在告知术前评估,以尝试识别那些最终病理报告可能最终存在 NIFTP 的患者,并为他们提供保守的手术计划,以协助对 NIFTP 患者进行具有成本效益的最佳管理。

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Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Cancer: Clinical Lessons from a Community-Based Endocrine Surgical Practice.甲状腺乳头状癌的非侵袭性包裹性滤泡变体:基于社区的内分泌外科实践的临床经验
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Metastatic Follicular Thyroid Carcinoma and the Primary Thyroid Gross Examination: Institutional Review of Cases from 1990 to 2015.转移性滤泡状甲状腺癌与原发性甲状腺大体检查:1990年至2015年病例的机构回顾
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Diagn Cytopathol. 2017 Jun;45(6):533-541. doi: 10.1002/dc.23709. Epub 2017 Mar 22.
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