Coca-Pelaz Andrés, Rodrigo Juan P, Agaimy Abbas, Hartl Dana M, Stenman Göran, Vander Poorten Vincent, Mäkitie Antti A, Zafereo Mark, Rao Karthik N, Randolph Gregory W, Rinaldo Alessandra, Ferlito Alfio
Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Av/ Roma s/n. 33011, Oviedo, Asturias, Spain.
Institute of Pathology, Friedrich Alexander University Erlangen-Nürnberg, University Hospital, Erlangen, Germany.
Virchows Arch. 2024 Dec;485(6):977-987. doi: 10.1007/s00428-024-03953-y. Epub 2024 Oct 23.
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently defined thyroid nodule category characterized by follicular architecture with papillary nuclear features but lacking classical papillary carcinoma features like papillae or psammoma bodies. The diagnosis of NIFTP is based on histological examination and excludes cases with high-risk mutations like BRAFV600E. NIFTP carries a low risk of recurrence and distant metastasis, prompting a more conservative surgical approach compared to classical papillary thyroid carcinoma. The management of NIFTP typically involves lobectomy with postoperative monitoring of thyroglobulin levels and performing neck ultrasounds. While the identification of NIFTP represents a significant advancement in thyroid cancer diagnosis, challenges remain in refining preoperative diagnostic tools and establishing optimal long-term follow-up strategies. The objective of this review is to provide a comprehensive overview of NIFTP, including its histopathological characteristics, molecular profile, clinical presentation, diagnostic criteria, management strategies, and future research directions.
具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP）是最近定义的一种甲状腺结节类型，其特征为具有乳头状核特征的滤泡结构，但缺乏如乳头或砂粒体等经典乳头状癌特征。NIFTP的诊断基于组织学检查，并排除具有BRAFV600E等高风险突变的病例。NIFTP的复发和远处转移风险较低，与经典乳头状甲状腺癌相比，促使采取更保守的手术方法。NIFTP的治疗通常包括甲状腺叶切除术，术后监测甲状腺球蛋白水平并进行颈部超声检查。虽然NIFTP的识别代表了甲状腺癌诊断的重大进展，但在完善术前诊断工具和建立最佳长期随访策略方面仍存在挑战。本综述的目的是全面概述NIFTP，包括其组织病理学特征、分子特征、临床表现、诊断标准、管理策略和未来研究方向。
