Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Head Neck. 2018 Nov;40(11):2538-2545. doi: 10.1002/hed.25319. Epub 2018 Jun 26.
Various studies have assessed the association between E-cadherin methylation and risk of nasopharyngeal cancer (NPC) but the conclusion remains unclear. This meta-analysis was conducted to evaluate the effects of E-cadherin methylation on the incidence and clinicopathological characteristics of NPC.
Ten studies published up to June 30, 2016, were collected. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized, respectively.
The E-cadherin methylation in NPC was significantly higher than those in normal groups (OR 16.23; 95% CI 8.34-31.60; P < .001). Ethnicity-stratified analysis indicated that E-cadherin methylation was strongly correlated with NPC among both Asians (OR 16.98; 95% CI 8.45-34.14; P < .001) and North Africans (OR 10.67; 95% CI 1.21-93.72; P = .033). However, further analysis showed that E-cadherin methylation was not strongly associated with clinicopathological feathers in patients with NPC.
The E-cadherin methylation is strongly associated with the incidence of NPC, which can serve as an effective biomarker for early detection of NPC.
多项研究评估了 E-钙黏蛋白甲基化与鼻咽癌（NPC）风险之间的关联，但结论仍不明确。本荟萃分析旨在评估 E-钙黏蛋白甲基化对 NPC 发生率和临床病理特征的影响。
收集截至 2016 年 6 月 30 日发表的 10 项研究。分别计算并总结了优势比（OR）及其相应的置信区间（CI）。
NPC 中的 E-钙黏蛋白甲基化显著高于正常组（OR 16.23；95%CI 8.34-31.60；P<0.001）。分层分析表明，E-钙黏蛋白甲基化与亚洲人（OR 16.98；95%CI 8.45-34.14；P<0.001）和北非人群（OR 10.67；95%CI 1.21-93.72；P=0.033）中的 NPC 显著相关。然而，进一步的分析表明，E-钙黏蛋白甲基化与 NPC 患者的临床病理特征无明显相关性。
E-钙黏蛋白甲基化与 NPC 的发生密切相关，可作为 NPC 早期检测的有效生物标志物。
