Kawahara Daisuke, Ozawa Shuichi, Tanaka Sodai, Yokomachi Kazushi, Higaki Toru, Saito Akito, Miki Kentaro, Fujioka Chikako, Ohno Yoshimi, Ohno Yoshimi, Kimura Tomoki, Murakami Yuji, Nagata Yasushi
1 Radiation Therapy Section, Division of Clinical Support, Hiroshima University Hospital , Hiroshima , Japan.
2 Medical and Dental Sciences Course, Graduate School of Biomedical & Health Sciences, Hiroshima University , Hiroshima , Japan.
Br J Radiol. 2018 Oct;91(1090):20180396. doi: 10.1259/bjr.20180396. Epub 2018 Jul 9.
: The purpose of the current study is to create a contrast medium extraction method using raw-data-based electron density (rED) and CT number from dual-energy CT (DECT) for automatic delineation of the contrast region.
: A CT-ED phantom containing tissue-equivalent inserts and an acrylic phantom with an iodinated contrast medium were scanned by DECT. The contrast medium extraction system was created using Python. The accuracy of the contrast medium extraction was evaluated by measuring the diameter in terms of the full width at half maximum (FWHM) and the ratio of the volume (ROV).
: Mean-2SD CT numbers and the difference of the CT numbers (DCT) of the contrast medium at 0-130 mg ml contrast medium concentration and the bone materials were more than -33 and -20 HU, respectively. In the correlation of rED and CT number, the gradient with the contrast medium phantom was greater than that with the CT-ED phantom. The accuracy of the contrast medium at 80 kV/135 kV and 100 kV/135 kV tube voltages. The gradient of the CT-ED and contrast medium phantoms were different. The gradient in the CT-ED phantom and the contrast medium was 0.0012 and 0.0003 at 80 kV/135 kV, and 0.0015 and 0.0005 at 100 kV/135 kV tube voltages, respectively. The ratio of the measured to the actual diameter in FWHM and ROV was 0.98-1.00 at 2-130 mg ml. At a tube voltage of 100 kV/135 kV. The ratio of the measured to the actual diameter in ROV was 0.66 and FWHM was 0.90 at 2 mg ml contrast medium concentration. The ratio of the measured to the actual diameter in FWHM and ROV was 0.98-1.00 at 3-130 mg ml.
: We created the contrast medium extraction method with rED and CT number images. The contrast medium extraction method could be used with DECT images at 80 kV/135 kV. The method is expected to only extract images from the region containing the contrast medium.
: We created the contrast medium extraction method using raw-data-based electron density and CT number from DECT and it is expected to only extract information from the region containing the contrast medium.
本研究的目的是创建一种基于双能CT（DECT）原始数据的电子密度（rED）和CT值的造影剂提取方法，用于自动勾勒造影区域。
使用DECT扫描包含组织等效插入物的CT-ED体模和含有碘化造影剂的丙烯酸体模。使用Python创建造影剂提取系统。通过测量半高宽（FWHM）的直径和体积比（ROV）来评估造影剂提取的准确性。
在造影剂浓度为0 - 130 mg/ml时，造影剂的平均-2SD CT值以及与骨材料的CT值差异（DCT）分别大于-33 HU和-20 HU。在rED与CT值的相关性方面，造影剂体模的梯度大于CT-ED体模。在80 kV/135 kV和100 kV/135 kV管电压下造影剂提取的准确性。CT-ED体模和造影剂体模的梯度不同。在80 kV/135 kV时，CT-ED体模和造影剂体模中的梯度分别为0.0012和0.0003；在100 kV/135 kV管电压下，分别为0.0015和0.0005。在造影剂浓度为2 - 130 mg/ml时，FWHM和ROV中测量直径与实际直径的比值为0.98 - 1.00。在管电压为100 kV/135 kV时，在造影剂浓度为2 mg/ml时，ROV中测量直径与实际直径的比值为0.66，FWHM为0.90。在造影剂浓度为3 - 130 mg/ml时，FWHM和ROV中测量直径与实际直径的比值为0.98 - 1.00。
我们创建了基于rED和CT值图像的造影剂提取方法。该造影剂提取方法可用于80 kV/135 kV的DECT图像。该方法有望仅从包含造影剂的区域提取图像。
我们使用基于DECT原始数据的电子密度和CT值创建了造影剂提取方法，并且有望仅从包含造影剂的区域提取信息。
