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Construction of frameshift mutation hot spots within the tetracycline resistance gene of pBR322.

作者信息

Burnouf D, Fuchs R P

出版信息

Biochimie. 1985 Mar-Apr;67(3-4):385-9. doi: 10.1016/s0300-9084(85)80085-7.

DOI:10.1016/s0300-9084(85)80085-7
PMID:2994756
Abstract

The chemical carcinogen, N-2-acetylaminofluorene (AAF) when bound covalently to DNA induces a majority (greater than 90%) of frameshift mutations. The mutations occur with high frequencies at defined sequences (i.e. mutation hot spots). Two classes of mutation hot spots were found: at repetitive sequences and at specific non-repetitive sequences. Mutations at the repetitive sequences depend upon a functional umuC gene whereas mutations at specific non-repetitive sequences are umuC-independent. The first discovered sequence of this class is the NarI restriction enzyme recognition sequence (5'GGCGCC3'). In an attempt to define a family of such sequences we constructed a related sequence 5'GCGCGC3' within the tetracycline resistance gene of pBR322. This sequence was also found to be an--AAF induced--2 frameshift mutation hot spot in both wild type and umuC strains.

摘要

相似文献

1
Construction of frameshift mutation hot spots within the tetracycline resistance gene of pBR322.
Biochimie. 1985 Mar-Apr;67(3-4):385-9. doi: 10.1016/s0300-9084(85)80085-7.
2
Carcinogen-induced mutation spectrum in wild-type, uvrA and umuC strains of Escherichia coli. Strain specificity and mutation-prone sequences.致癌物诱导的大肠杆菌野生型、uvrA和umuC菌株中的突变谱。菌株特异性和易突变序列。
J Mol Biol. 1984 Jul 25;177(1):33-51. doi: 10.1016/0022-2836(84)90056-1.
3
Specificity of N-acetoxy-N-2-acetylaminofluorene-induced frameshift mutation spectrum in mismatch repair deficient Escherichia coli strains mutH, L, S and U.错配修复缺陷型大肠杆菌菌株mutH、L、S和U中N-乙酰氧基-N-2-乙酰氨基芴诱导的移码突变谱的特异性
J Mol Biol. 1986 Aug 5;190(3):499-507. doi: 10.1016/0022-2836(86)90018-5.
4
Sequence determinants for -2 frameshift mutagenesis at NarI-derived hot spots.NarI衍生热点处-2移码诱变的序列决定因素。
J Mol Biol. 1995 Oct 6;252(5):507-13. doi: 10.1006/jmbi.1995.0515.
5
Position of a single acetylaminofluorene adduct within a mutational hot spot is critical for the related mutagenic event.
Basic Life Sci. 1990;52:277-87. doi: 10.1007/978-1-4615-9561-8_23.
6
Induction of -2 frameshift mutations within alternating GC sequences by carcinogens that bind to the C8 position of guanine residues: development of a specific mutation assay.通过与鸟嘌呤残基的C8位结合的致癌物在交替GC序列中诱导-2移码突变：一种特异性突变检测方法的开发
Mol Gen Genet. 1990 May;221(3):331-8. doi: 10.1007/BF00259396.
7
Single adduct mutagenesis: strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.单加合物诱变：单个乙酰氨基芴加合物在突变热点内的位置具有强烈影响。
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4147-51. doi: 10.1073/pnas.86.11.4147.
8
Sequence-dependent modulation of frameshift mutagenesis at NarI-derived mutation hot spots.在源自NarI的突变热点处移码诱变的序列依赖性调控。
J Mol Biol. 1999 Apr 23;288(1):191-9. doi: 10.1006/jmbi.1999.2667.
9
DNA sequence analysis of mutations induced by N-2-acetylamino-7-iodofluorene in plasmid pBR322 in Escherichia coli.N-2-乙酰氨基-7-碘芴在大肠杆菌质粒pBR322中诱导产生的突变的DNA序列分析
J Mol Biol. 1990 May 20;213(2):239-46. doi: 10.1016/S0022-2836(05)80187-1.
10
Strong structural effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.单个乙酰氨基芴加合物在突变热点内位置的强大结构效应。
Nucleic Acids Res. 1989 Dec 11;17(23):9531-41. doi: 10.1093/nar/17.23.9531.

引用本文的文献

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Processing closely spaced lesions during Nucleotide Excision Repair triggers mutagenesis in E. coli.在核苷酸切除修复过程中处理紧密间隔的损伤会引发大肠杆菌中的诱变。
PLoS Genet. 2017 Jul 7;13(7):e1006881. doi: 10.1371/journal.pgen.1006881. eCollection 2017 Jul.
2
Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutation.静止期细胞亚群中的全基因组超突变是依赖重组的适应性突变的基础。
EMBO J. 1997 Jun 2;16(11):3303-11. doi: 10.1093/emboj/16.11.3303.
3
SOS factors involved in translesion synthesis.
参与跨损伤合成的SOS因子。
Proc Natl Acad Sci U S A. 1997 May 27;94(11):5733-8. doi: 10.1073/pnas.94.11.5733.
4
MucAB but not UmuDC proteins enhance -2 frameshift mutagenesis induced by N-2-acetylaminofluorene at alternating GC sequences.MucAB蛋白而非UmuDC蛋白可增强N-2-乙酰氨基芴在交替GC序列处诱导的-2移码突变。
Mol Gen Genet. 1994 Nov 1;245(3):279-85. doi: 10.1007/BF00290107.
5
Single adduct mutagenesis: strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot.单加合物诱变：单个乙酰氨基芴加合物在突变热点内的位置具有强烈影响。
Proc Natl Acad Sci U S A. 1989 Jun;86(11):4147-51. doi: 10.1073/pnas.86.11.4147.
6
Genetic control of AAF-induced mutagenesis at alternating GC sequences: an additional role for RecA.在交替的GC序列处AAF诱导的诱变的遗传控制：RecA的另一个作用。
Mol Gen Genet. 1989 Jan;215(2):306-11. doi: 10.1007/BF00339733.
7
Z-DNA-forming sequences are spontaneous deletion hot spots.
Proc Natl Acad Sci U S A. 1989 Oct;86(19):7465-9. doi: 10.1073/pnas.86.19.7465.
8
Activity of carcinogens that bind to the C8 position of guanine residues in an assay specific for the detection of -2 frameshift mutations in a defined hot spot.在一项针对特定热点区域-2移码突变检测的试验中，与鸟嘌呤残基C8位置结合的致癌物活性。
Environ Health Perspect. 1990 Aug;88:83-7. doi: 10.1289/ehp.908883.
9
Induction of -2 frameshift mutations within alternating GC sequences by carcinogens that bind to the C8 position of guanine residues: development of a specific mutation assay.通过与鸟嘌呤残基的C8位结合的致癌物在交替GC序列中诱导-2移码突变：一种特异性突变检测方法的开发
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10
A umuDC-independent SOS pathway for frameshift mutagenesis.一种不依赖umuDC的移码诱变SOS途径。
Mol Gen Genet. 1992 Nov;235(2-3):373-80. doi: 10.1007/BF00279383.