γ-氨基丁酸对离体青蛙视顶盖神经元突触传递的一种异常效应。
An unusual effect of gamma-aminobutyric acid on synaptic transmission of frog tectal neurones in vitro.
作者信息
Nistri A, Sivilotti L
出版信息
Br J Pharmacol. 1985 Aug;85(4):917-21. doi: 10.1111/j.1476-5381.1985.tb11092.x.
Abstract
Bath-applied gamma-aminobutyric acid (GABA) enhanced, in a dose-dependent fashion, the amplitude of optic nerve-evoked monosynaptic excitatory responses of the frog optic tectum superfused in vitro at 7 degrees C. Muscimol was more potent than GABA in eliciting similar effects. GABA-induced responses were antagonized by picrotoxin and were insensitive to bicuculline or strychnine. Raising the bath temperature to 20 degrees C reduced the potency of GABA on these preparations. No significant effect of GABA on the compound action potential of the whole optic nerve was found. These data indicate that GABA can amplify visual inputs to the tectum through bicuculline-insensitive mechanisms.
摘要
浴用γ-氨基丁酸（GABA）以剂量依赖性方式增强了在7℃下体外灌流的青蛙视顶盖中视神经诱发的单突触兴奋性反应的幅度。蝇蕈醇在引发类似效应方面比GABA更有效。GABA诱导的反应被印防己毒素拮抗，并且对荷包牡丹碱或士的宁不敏感。将浴温提高到20℃会降低GABA对这些制剂的效力。未发现GABA对整个视神经的复合动作电位有显著影响。这些数据表明，GABA可通过对荷包牡丹碱不敏感的机制放大对视顶盖的视觉输入。
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