Aix-Marseille Univ, CNRS, Centrale Marseille, iSm2, Avenue Escadrille Normandie Niemen, 13013, Marseille, France.
Service Commun des Laboratoires du Ministère des Finances, Laboratoire de Marseille, 13388, Marseille, France.
Anal Bioanal Chem. 2018 Aug;410(21):5237-5244. doi: 10.1007/s00216-018-1175-7. Epub 2018 Jun 12.
Seized samples of illegally produced cocaine have a very large variability in composition; a fact that may result in a challenge to their analysis. We demonstrate here a simple and fast method to detect the presence of cocaine in both hydrochloride and free-base forms in illicit drug samples by nuclear magnetic resonance (NMR) spectroscopy. This is achieved by combining the commonly used 1D spectra and diffusion-ordered spectroscopy and introducing the 2D maximum-quantum NMR approach to forensic analysis. The protocol allows the facile determination of the cocaine forms even in the presence of multiple adulterants. By relying on non-uniform sampling acceleration of 2D spectroscopy, the identification can be obtained in less than 3 min for 10 mg of product. Moreover, we show that intermolecular interactions of the sample constituents, while affecting the analysis result, do not interfere with the quality of the detection of the proposed protocol.
被扣押的非法生产可卡因样本在成分上有很大的可变性；这一事实可能对其分析提出挑战。我们在这里展示了一种简单而快速的方法，通过核磁共振（NMR）光谱法检测非法药物样本中盐酸可卡因和游离碱形式的可卡因的存在。这是通过结合常用的一维谱和扩散有序光谱，并引入二维最大量子 NMR 方法来实现的。该方案允许在存在多种掺杂物的情况下轻松确定可卡因的形式。通过对二维光谱进行非均匀采样加速，对于 10 毫克的产物，识别可以在不到 3 分钟内获得。此外，我们还表明，虽然样品成分的分子间相互作用会影响分析结果，但不会干扰所提出方案的检测质量。
