Biophysics Department, Universidade Federal do Rio Grande do Sul, Bento Gonçalves Avenue, 9500, prédio 43422, room 204, Porto Alegre, 91501-970, Brazil.
Post-Graduation Program in Cellular and Molecular Biology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Eur Arch Otorhinolaryngol. 2018 Aug;275(8):2027-2033. doi: 10.1007/s00405-018-5034-0. Epub 2018 Jun 11.
Nasal polyposis is a chronic inflammatory disease of the mucosa of the nasal cavity and paranasal sinuses. The etiology of nasal polyposis is unclear; however, it may be associated with asthma and intolerance to acetylsalicylic acid, possibly altering the redox profile. The study intends to compare the redox profile in polyps surgically removed from three clinical groups of patients with nasal polyposis who were divided according to the presence of asthma and intolerance to acetylsalicylic acid.
Patients were divided into three groups: nasal polyposis only (n = 30); nasal polyposis and asthma (n = 19); and nasal polyposis, asthma and intolerance to acetylsalicylic acid (n = 10). The following redox evaluations were performed: enzymatic antioxidant activity of superoxide dismutase, glutathione peroxidase, hydrogen peroxide consumption and glutathione S-transferase; non-enzymatic antioxidant levels of vitamin C, vitamin E and glutathione; levels of the oxidative damage biomarkers carbonyl groups (measuring protein damage) and malondialdehyde (measuring lipid peroxidation); and nitrite and nitrate levels.
Compared with the polyposis only group, hydrogen peroxide consumption, glutathione S-transferase, vitamin E and malondialdehyde were lower in the asthma group. Total glutathione (0.12 ± 0.01 vs. 33.34 ± 10.48 µmol/mg) and nitrite and nitrate (0.06 ± 0.01 vs. 15.95 ± 1.38 nmol/mg) levels were higher in the nasal polyposis, asthma and intolerance to acetylsalicylic acid group.
In patients with nasal polyposis, asthma may alter the redox profile associated with the hydrogen peroxide and lipid damage pathways, whereas asthma and intolerance to acetylsalicylic acid increase nitrite and nitrate and total glutathione levels.
鼻息肉是鼻腔和鼻窦黏膜的慢性炎症性疾病。鼻息肉的病因尚不清楚；然而，它可能与哮喘和对乙酰水杨酸不耐受有关，可能改变氧化还原状态。本研究旨在比较根据哮喘和对乙酰水杨酸不耐受的存在将鼻息肉患者分为三组后手术切除的息肉中的氧化还原状态。
患者分为三组：单纯鼻息肉（n = 30）；鼻息肉伴哮喘（n = 19）；鼻息肉、哮喘和对乙酰水杨酸不耐受（n = 10）。进行以下氧化还原评估：超氧化物歧化酶、谷胱甘肽过氧化物酶、过氧化氢消耗和谷胱甘肽 S-转移酶的酶抗氧化活性；维生素 C、维生素 E 和谷胱甘肽的非酶抗氧化水平；羰基（测量蛋白质损伤）和丙二醛（测量脂质过氧化）的氧化损伤生物标志物水平；以及亚硝酸盐和硝酸盐水平。
与单纯鼻息肉组相比，哮喘组过氧化氢消耗、谷胱甘肽 S-转移酶、维生素 E 和丙二醛降低。总谷胱甘肽（0.12 ± 0.01 与 33.34 ± 10.48 µmol/mg）和亚硝酸盐和硝酸盐（0.06 ± 0.01 与 15.95 ± 1.38 nmol/mg）水平在鼻息肉、哮喘和对乙酰水杨酸不耐受组中更高。
在鼻息肉患者中，哮喘可能改变与过氧化氢和脂质损伤途径相关的氧化还原状态，而哮喘和对乙酰水杨酸不耐受增加亚硝酸盐和硝酸盐以及总谷胱甘肽水平。
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