Sagit M, Erdamar H, Saka C, Yalcin S, Akin I
Department of ENT, Kayseri Training and Research Hospital, Kayseri, Turkey.
J Laryngol Otol. 2011 Aug;125(8):811-5. doi: 10.1017/S0022215111001149. Epub 2011 Jun 14.
To investigate the therapeutic effects of antioxidants on the clinical and biochemical outcome of patients with nasal polyposis.
Thirty-four patients with nasal polyposis were divided into two groups receiving either intranasal steroid or intranasal steroid plus per-oral vitamins A, C and E and selenium. Paranasal sinus computed tomography, endoscopy, and polyp tissue and serum sampling were conducted pre- and post-therapy. Serum levels of malondialdehyde, superoxide dismutase, nitrite and myeloperoxidase and tissue levels of malondialdehyde and superoxide dismutase were measured. Group results were compared using the Mann-Whitney U test and Wilcoxon signed-rank test.
Both groups had significantly lower tissue parameters, computed tomography scores and serum malondialdehyde levels, comparing pre- versus post-treatment results. Post-treatment, the steroid plus antioxidant group had significantly lower tissue malondialdehyde levels and a greater fall in tissue and serum malondialdehyde, compared with the steroid group.
Serum and tissue levels of malondialdehyde (an oxidative marker) were significantly decreased by adding antioxidants to standard therapy. This is the first report of the positive effects of adding antioxidants to steroid therapy for nasal polyposis.
探讨抗氧化剂对鼻息肉患者临床及生化指标的治疗效果。
34例鼻息肉患者分为两组，分别接受鼻内类固醇治疗或鼻内类固醇联合口服维生素A、C、E及硒治疗。治疗前后进行鼻窦计算机断层扫描、鼻内镜检查，并采集息肉组织和血清样本。检测血清丙二醛、超氧化物歧化酶、亚硝酸盐和髓过氧化物酶水平以及组织丙二醛和超氧化物歧化酶水平。采用Mann-Whitney U检验和Wilcoxon符号秩检验比较两组结果。
与治疗前相比，两组治疗后的组织参数、计算机断层扫描评分和血清丙二醛水平均显著降低。治疗后，与类固醇组相比，类固醇加抗氧化剂组的组织丙二醛水平显著降低，组织和血清丙二醛下降幅度更大。
在标准治疗中添加抗氧化剂可显著降低丙二醛（一种氧化标志物）的血清和组织水平。这是关于在鼻息肉类固醇治疗中添加抗氧化剂具有积极作用的首份报告。
