Haglund M M, Stahl W L, Kunkel D D, Schwartzkroin P A
Brain Res. 1985 Sep 16;343(1):198-203. doi: 10.1016/0006-8993(85)91180-1.
Regional differences in Na,K-ATPase activity, and development of Na,K-ATPase activity were examined in rabbit hippocampus using a histochemical marker of enzyme activity. Stratum lucidum of CA3/CA2, corresponding to the mossy fiber terminal field, showed high Na,K-ATPase activity compared to stratum radiatum of CA1. A significant increase in Na,K-ATPase activity was found between 8 and 15 days postnatal. Tissues with limited Na,K-ATPase activity (immature hippocampus, the mature CA1 region) appear particularly prone to seizure-like abnormalities, perhaps reflecting an inability to regulate extracellular potassium.
利用酶活性的组织化学标记物，研究了兔海马体中钠钾ATP酶活性的区域差异以及钠钾ATP酶活性的发育情况。与CA1的辐射层相比，对应于苔藓纤维终末场的CA3/CA2的透明层显示出较高的钠钾ATP酶活性。在出生后8至15天之间发现钠钾ATP酶活性显著增加。钠钾ATP酶活性有限的组织（未成熟海马体、成熟的CA1区域）似乎特别容易出现癫痫样异常，这可能反映了调节细胞外钾的能力不足。
