Ying Jian, Zhou Min-Jie, Chen Hai-Yong, Chen Lei, Zhang Wei, Ji Jun, Yu Chao, Zhang Zhang-Jin
Department of Urology and Andrology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Shanghai Qigong Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, China.
Chin J Integr Med. 2019 Feb;25(2):91-95. doi: 10.1007/s11655-018-2797-5. Epub 2018 Jun 8.
To evaluate the efficacy and safety of essential oil treatment for type III chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
A randomized controlled trial was conducted from December 2014 to October 2015. Seventy type III CP/CPPS patients were assigned to the essential oil group (35 cases) or almond placebo oil control group (35 cases) by a random number table. The oil was smeared by self-massage on the suprapubic and sacral region once a day for 4 weeks. The National Institutes of Health Chronic Prostatitis Syndrome Index (NIH-CPSI) and expressed prostatic secretions (EPS) were examined. The primary outcome was NIH-CPSI pain domain. The secondary outcomes included other NIH-CPSI domains and laboratory examinations of EPS. Adverse events were also observed.
Sixty-six subjects completed the full 4-week treatment. There was no significant difference between almond oil control and essential oil groups in terms of the total score of NIH-CPSI, pain, quality of life and urination domain scores of NIH-CPSI and EPS examinations (P>0.05). In the essential oil group, pain between rectum and testicles (perineum) in the domain of pain or discomfort was significantly reduced at week 2 and week 4 compared with almond oil control group (P<0.01). No serious adverse events occurred.
The essential oil may reduce the pain or discomfort in the perineum region in patients with CP/CPPS. (Registration No. ChiCTR-IPR-14005448).
评估精油治疗Ⅲ型慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）的疗效和安全性。
于2014年12月至2015年10月进行一项随机对照试验。通过随机数字表将70例Ⅲ型CP/CPPS患者分为精油组（35例）和杏仁安慰剂油对照组（35例）。患者自行按摩，将油涂抹于耻骨上区和骶区，每日1次，共4周。检测美国国立卫生研究院慢性前列腺炎症状指数（NIH-CPSI）和前列腺液（EPS）。主要结局指标为NIH-CPSI疼痛域。次要结局指标包括NIH-CPSI的其他域以及EPS的实验室检查。同时观察不良事件。
66名受试者完成了为期4周的完整治疗。杏仁油对照组和精油组在NIH-CPSI总分、疼痛、生活质量、NIH-CPSI排尿域评分及EPS检查方面无显著差异（P>0.05）。与杏仁油对照组相比，精油组在第2周和第4周时，疼痛或不适域中直肠与睾丸之间（会阴部）的疼痛显著减轻（P<0.01）。未发生严重不良事件。
精油可能减轻CP/CPPS患者会阴部区域的疼痛或不适。（注册号：ChiCTR-IPR-14005448）
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