振幅整合脑电图预测急性脑损伤后昏迷患者的预后。
Amplitude-Integrated Electroencephalography Predicts Outcome in Patients with Coma After Acute Brain Injury.
机构信息
Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Shanghai Institute of Head Trauma, Shanghai, 200127, China.
出版信息
Neurosci Bull. 2018 Aug;34(4):639-646. doi: 10.1007/s12264-018-0241-7. Epub 2018 Jun 9.
Prognostication of coma patients after brain injury is important, yet challenging. In this study, we evaluated the predictive value of amplitude-integrated electroencephalography (aEEG) for neurological outcomes in coma patients. From January 2013 to January 2016, 128 coma patients after acute brain injury were prospectively enrolled and monitored with aEEG. The 6-month neurological outcome was evaluated using the Cerebral Performance Category Scale. aEEG monitoring commenced at a median of 7.5 days after coma onset. Continuous normal voltage predicted a good 6-month neurological outcome with a sensitivity of 93.6% and specificity of 85.2%. In contrast, continuous extremely low voltage, burst-suppression, or a flat tracing was correlated with poor 6-month neurological outcome with a sensitivity of 76.5% and specificity of 100%. In conclusion, aEEG is a promising predictor of 6-month neurological outcome for coma patients after acute brain injury.
昏迷患者的预后评估非常重要，但也极具挑战性。本研究旨在评估脑损伤后昏迷患者的振幅整合脑电图（aEEG）对神经功能结局的预测价值。2013 年 1 月至 2016 年 1 月，前瞻性纳入了 128 例急性脑损伤后昏迷患者，并使用 aEEG 进行监测。采用脑功能预后量表（Cerebral Performance Category Scale）评估患者 6 个月时的神经功能结局。aEEG 监测在昏迷发生后中位数 7.5 天开始。连续正常电压预测 6 个月时神经功能结局良好的灵敏度为 93.6%，特异性为 85.2%。相反，连续出现极低电压、爆发抑制或平坦波与 6 个月时神经功能结局不良相关，其灵敏度为 76.5%，特异性为 100%。总之，aEEG 是急性脑损伤后昏迷患者 6 个月神经功能结局的一种有前景的预测指标。
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