Nishimura Akiko, Harashima Shin-Ichi, Hosoda Kiminori, Inagaki Nobuya
Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Diabetes, Endocrinology and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Diabetes Ther. 2018 Aug;9(4):1501-1510. doi: 10.1007/s13300-018-0457-6. Epub 2018 Jun 12.
This article evaluates the potential long-term effect of two different color indication methods for self-monitoring of blood glucose (SMBG), the color record (CR) and color display (CD), on metabolic parameters in insulin-treated type 2 diabetes in a post-intervention period.
101 participants with type 2 diabetes who completed the Color IMPACT study were enrolled in a 2-year comparison follow-up study. Participants continued SMBG with their usual diabetes care. The study outcomes were differences in change in HbA1c levels, blood pressure (BP), body weight and lipid profiles between the CR and non-CR arms and the CD and non-CD arms during a 1- and 2-year period of the study.
98 participants were analyzed. Reductions in HbA1c levels, systolic BP and low-density lipoprotein cholesterol levels were maintained in the CR arm by - 0.40% (95% CI: - 0.73 to - 0.06, p = 0.020), -1 3.2 mmHg (95% CI: - 24.1 to - 2.3, p = 0.019), - 11.4 mg/dl (95% CI: - 18.1 to - 4.6, p = 0.001), respectively, in a 1-year period. However, HbA1c and BP returned to the baseline levels during an additional 1-year period. In contrast, there were no significant changes in outcome in the CD arm during the study period.
Intervention promoting self-action such as the color record method in SMBG sustains a beneficial effect on metabolic parameters after the intervention. This long-term effect is helpful for people with type 2 diabetes to manage their diabetes ABCs (HbA1c, BP, cholesterol) and to prevent diabetic complications.
UMIN clinical trials registry identifier, UMIN000006865.
本文评估了两种不同的血糖自我监测（SMBG）颜色指示方法，即颜色记录（CR）和颜色显示（CD），在干预后期对胰岛素治疗的2型糖尿病患者代谢参数的潜在长期影响。
101名完成“颜色影响”研究的2型糖尿病参与者被纳入一项为期2年的对比随访研究。参与者继续进行自我血糖监测，并接受常规糖尿病护理。研究结果是在研究的1年和2年期间，CR组与非CR组以及CD组与非CD组之间糖化血红蛋白（HbA1c）水平、血压（BP）、体重和血脂谱变化的差异。
对98名参与者进行了分析。在1年期间，CR组的HbA1c水平、收缩压和低密度脂蛋白胆固醇水平分别降低了-0.40%（95%置信区间：-0.73至-0.06，p = 0.020）、-13.2 mmHg（95%置信区间：-24.1至-2.3，p = 0.019）、-11.4 mg/dl（95%置信区间：-18.1至-4.6，p = 0.001）。然而，在接下来的1年期间，HbA1c和血压恢复到了基线水平。相比之下，在研究期间，CD组的结果没有显著变化。
促进自我行动的干预措施，如血糖自我监测中的颜色记录法，在干预后对代谢参数具有持续的有益影响。这种长期影响有助于2型糖尿病患者管理其糖尿病ABC（HbA1c、血压、胆固醇）并预防糖尿病并发症。
UMIN临床试验注册标识符，UMIN000006865。
