Schweisfurth H, Schmidt M, Brugger E, Maiwald L, Thiel H
Clin Biochem. 1985 Aug;18(4):242-6. doi: 10.1016/s0009-9120(85)80049-7.
The activities of serum carboxypeptidases N (E.C. 3.4.17.3) and serum angiotensin-I-converting enzyme (E.C. 3.4.15.1) were spectrophotometrically measured in patients with hematological disorders and in histologically proven bronchogenic carcinomas. The enzyme activities have been compared with various laboratory parameters. Controls were healthy subjects. No significant sex differences of carboxypeptidases N and angiotensin-I-converting enzyme were found in the healthy controls or in the whole patients' group. The carboxypeptidases N were significantly elevated in patients with lung cancer (p less than 0.0001) compared to the healthy controls. The angiotensin-I-converting enzyme was significantly reduced (p less than 0.0001) in serum of patients with bronchogenic carcinoma. In responders to chemo- and/or radiotherapy, the carboxypeptidases decreased and the angiotensin-I-converting enzyme increased to normal enzyme values. In non-responders to these therapies no change in these enzymes could be observed.
采用分光光度法测定了血液系统疾病患者和经组织学证实的支气管源性肺癌患者血清羧肽酶N（E.C. 3.4.17.3）和血清血管紧张素I转换酶（E.C. 3.4.15.1）的活性。已将酶活性与各种实验室参数进行了比较。对照组为健康受试者。在健康对照组或整个患者组中，未发现羧肽酶N和血管紧张素I转换酶存在显著的性别差异。与健康对照组相比，肺癌患者的羧肽酶N显著升高（p＜0.0001）。支气管源性肺癌患者血清中的血管紧张素I转换酶显著降低（p＜0.0001）。在对化疗和/或放疗有反应的患者中，羧肽酶降低，血管紧张素I转换酶升高至正常酶值。在对这些治疗无反应的患者中，未观察到这些酶有变化。
