Wang H Z, Jin Y, Wang P, Han C, Wang Z P, Dong M Y
Clin Exp Obstet Gynecol. 2017;44(3):419-422.
Endocan is a novel marker for inflammation but its significance in preeclampsia remains unknown.
The aims of this study were to delineate the changes of maternal endocan in normal pregnancy and preeclampsia and to explore its possible role in the pathogenesis of preeclampsia.
Blood samples were taken from 42 non-pregnant women, from 43 normal pregnant women at third trimester, and from 41 preeclamptic women. Serum endocan levels were determined with enzyme-linked immunosorbent assay (ELISA) and compared among the groups.
There were no significant differences in serum endocan among non-pregnant women, normal pregnant women, and women with preeclampsia (X²= 2.207, p = 0.137) and there was no significant difference in serum endocan between women with mild and severe preeclampsia (Z= 0.368, p = 0. 713). The authors concluded that serum endocan did not change in pregnancy and preeclampsia, indicating endocan may not be involved in the pathogenesis of preeclampsia.
内皮抑素是一种新型炎症标志物，但其在子痫前期中的意义尚不清楚。
本研究旨在描述正常妊娠和子痫前期孕妇体内内皮抑素的变化，并探讨其在子痫前期发病机制中的可能作用。
采集42名未孕女性、43名孕晚期正常孕妇和41名子痫前期孕妇的血样。采用酶联免疫吸附测定法（ELISA）测定血清内皮抑素水平，并在各组间进行比较。
未孕女性、正常孕妇和子痫前期孕妇的血清内皮抑素水平无显著差异（X² = 2.207，p = 0.137），轻度和重度子痫前期孕妇的血清内皮抑素水平也无显著差异（Z = 0.368，p = 0.713）。作者得出结论，妊娠和子痫前期时血清内皮抑素无变化，表明内皮抑素可能不参与子痫前期的发病机制。
