Fernandez D, Fernandez P G, Snedden W, Kim B K, Triggle C R, Idikio H, Lee C C
Clin Invest Med. 1985;8(3):208-13.
Enalapril maleate and hydrochlorothiazide were administered over an 8-week period to groups of Dahl salt-sensitive and Dahl salt-resistant rats receiving either a high (8%) or low (0.4%) salt diet. Regional differences of interventricular septal thickness, left ventricular free wall thickness, right ventricular free wall thickness, right ventricular weight/body weight ratio, left ventricular weight/body ratio, and heart weights were determined. For salt-sensitive rats of both diet groups, lowering of blood pressure induced by either drug was associated with a reduction in cardiac weight which was localized to the left ventricle. For salt-resistant rats, irrespective of diet, the associated reduction of cardiac mass induced by enalapril maleate was largely confined to the right ventricle. Regional changes in tissue thickness were, however, not always associated with corresponding changes in tissue mass or blood pressure. These regional modulations appeared to be quite dependent on salt intake and the nature of the antihypertensive drug, for a given animal type, suggesting that pressure afterload is not the only factor in the pathogenesis of left and right ventricular hypertrophy. The responses of the right ventricle were not necessarily the same as those of the left ventricle to identical dietary and drug regimens. In all animal groups, ventricular mass and tissue thickness did not always change in the same sense, suggesting that alterations in the nature and packaging of the cellular constituents may be induced by the combined actions of the dietary salt and antihypertensive medications.
在为期8周的时间里，将马来酸依那普利和氢氯噻嗪给予接受高盐（8%）或低盐（0.4%）饮食的Dahl盐敏感型和Dahl盐抵抗型大鼠组。测定室间隔厚度、左心室游离壁厚度、右心室游离壁厚度、右心室重量/体重比、左心室重量/体重比以及心脏重量的区域差异。对于两个饮食组的盐敏感型大鼠，两种药物引起的血压降低均与心脏重量的减轻相关，且这种减轻局限于左心室。对于盐抵抗型大鼠，无论饮食如何，马来酸依那普利引起的心脏质量的相关减轻主要局限于右心室。然而，组织厚度的区域变化并不总是与组织质量或血压的相应变化相关。对于给定的动物类型，这些区域调节似乎相当依赖于盐摄入量和抗高血压药物的性质，这表明压力后负荷不是左、右心室肥厚发病机制中的唯一因素。右心室对相同饮食和药物方案的反应不一定与左心室相同。在所有动物组中，心室质量和组织厚度并不总是朝着相同的方向变化，这表明饮食盐和抗高血压药物的联合作用可能会诱导细胞成分的性质和包装发生改变。
