Grechko O Yu, Shtareva D M, Spasov A A, Litvinov L A, Rashchenko A I
Eksp Klin Farmakol. 2016 Aug;79(4):8-11.
We have studied the physical dependence on and tolerance to the analgesic activity of compound RU-1205. It is established that this compound does not cause side effects typical of morphine and butorphanol including the development of withdrawal syndrome upon naloxone provocation and tolerance to analgesic activity upon 14-day administration.