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STUDYING THE PHYSICAL DEPENDENCE ON AND TOLERANCE TO THE ANTINOCICEPTIVE EFFECT OF RU-1205 SUBSTANCE.

作者信息

Grechko O Yu, Shtareva D M, Spasov A A, Litvinov L A, Rashchenko A I

出版信息

Eksp Klin Farmakol. 2016 Aug;79(4):8-11.

Abstract

We have studied the physical dependence on and tolerance to the analgesic activity of compound RU-1205. It is established that this compound does not cause side effects typical of morphine and butorphanol including the development of withdrawal syndrome upon naloxone provocation and tolerance to analgesic activity upon 14-day administration.

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