Vanchugova N N, Privalova L I, Komissarova O V, Grebennikov S A
Eksp Onkol. 1985;7(4):65-6.
The effect of some carcinogenic and non-carcinogenic agents on the content of CFUs and frequency of micronuclei (Howell-Jolly corps) in polychromatic erythrocytes of bone marrow cells was studied in CBA mice. Benzene administration decreased the content of CFUs in bone marrow cells, but this effect is considered to be rather a sign of its hematotropic than carcinogenic action. Changes in the CFUs amount induced by chrysotile-asbestos and quartz DQ-12 action were insignificant. All investigated carcinogenic agents (benz(a)pyrene, asbestos and benzene) significantly increased the number of micronuclei in polychromatic erythrocytes of bone marrow in mice.
在CBA小鼠中研究了某些致癌和非致癌剂对骨髓细胞多染红细胞中集落形成单位（CFU）含量和微核（豪厄尔-乔利小体）频率的影响。给予苯会降低骨髓细胞中CFU的含量，但这种作用被认为更像是其对血液的作用而非致癌作用的标志。温石棉和石英DQ-12作用引起的CFU数量变化不显著。所有研究的致癌剂（苯并(a)芘、石棉和苯）均显著增加了小鼠骨髓多染红细胞中的微核数量。
