Sukumar Deeptha, Becker Kendra B, Cheung May, Diamond Samantha, Duszak Rittane, Aljahdali Abeer, Volpe Stella L, Nasser Jennifer A
1 Department of Nutrition Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, USA.
Nutr Health. 2018 Sep;24(3):153-162. doi: 10.1177/0260106018777336. Epub 2018 Jun 27.
: Bone-regulating hormones and nutrients play an important role in influencing metabolic health.
: The aim of this study was to determine whether bone-regulating hormones and nutrients, such as parathyroid hormone (PTH), 25-hydroxyvitamin D (25OHD), and magnesium (Mg) could be used to characterize the metabolically healthy obese (MHO) phenotype.
: This study included 27 overweight or obese participants (14 men/13 women) classified as MHO ( n = 14) or metabolically unhealthy obese (MUO) ( n = 13) based on the presence or absence of metabolic abnormalities, determined by percentage body fat, percentage trunk fat, and waist circumference. Biochemical (serum concentrations of hormones and cytokines such as PTH, 25OHD, ionized Mg (iMg), cytokines, lipids, glycemic indices), physiological (percentage body fat, percentage trunk fat, blood pressure (BP)), and dietary intake (Mg intake, calcium intake) measurements were obtained.
: Serum PTH concentrations were significantly lower ( p = 0.005) in the MHO group (39.68 ± 11.06 pg/mL) compared with the MUO group (63.78 ± 25.82 pg/mL). Serum iMg concentrations were higher ( p = 0.052) in the MHO group (0.565 ± 0.41 mmol/L) than in the MUO group (0.528 ± 0.050 mmol/L). Serum concentrations of osteocalcin were also higher (10.37 ± 3.70 ng/mL) in the MHO compared with the MUO (6.51 ± 4.14 ng/mL) group ( p = 0.017). The MHO group had significantly lower serum insulin concentrations ( p = 0.006) and diastolic BP ( p = 0.035). Concentrations of serum 25OHD, total triglycerides, C-reactive protein and systolic BP did not differ between groups.
: These findings suggest that bone-regulating hormones and nutrients, especially serum PTH, osteocalcin concentrations, and dietary Mg intakes, can help to characterize the MHO phenotype.
骨调节激素和营养素在影响代谢健康方面发挥着重要作用。
本研究的目的是确定骨调节激素和营养素，如甲状旁腺激素（PTH）、25-羟基维生素D（25OHD）和镁（Mg）是否可用于表征代谢健康的肥胖（MHO）表型。
本研究纳入了27名超重或肥胖参与者（14名男性/13名女性），根据是否存在代谢异常分为MHO组（n = 14）或代谢不健康的肥胖（MUO）组（n = 13），代谢异常通过体脂百分比、躯干脂肪百分比和腰围来确定。获取了生化指标（血清中激素和细胞因子的浓度，如PTH、25OHD、离子化镁（iMg）、细胞因子、脂质、血糖指数）、生理指标（体脂百分比、躯干脂肪百分比、血压（BP））和饮食摄入量（镁摄入量、钙摄入量）的测量值。
与MUO组（63.78 ± 25.82 pg/mL）相比，MHO组（39.68 ± 11.06 pg/mL）的血清PTH浓度显著降低（p = 0.005）。MHO组（0.565 ± 0.41 mmol/L）的血清iMg浓度高于MUO组（0.528 ± 0.050 mmol/L）（p = 0.052）。与MUO组（6.51 ± 4.14 ng/mL）相比，MHO组的血清骨钙素浓度也更高（10.37 ± 3.70 ng/mL）（p = 0.017）。MHO组的血清胰岛素浓度（p = 0.006）和舒张压（p = 0.035）显著更低。两组之间血清25OHD、总甘油三酯、C反应蛋白和收缩压的浓度没有差异。
这些发现表明，骨调节激素和营养素，特别是血清PTH、骨钙素浓度和饮食中的镁摄入量，有助于表征MHO表型。
