[造血干细胞还是造血祖细胞维持稳态造血？-编者按]
[Hematopoietic Stem Cells or Hematopoietic Progenitor Cells Maintain the Steady-State Hematopoiesis? -Editorial].
作者信息
Zhang Shan-Shan, Dong Fang, Cheng Tao, Hideo Ema
机构信息
State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China; Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin 300020, China; Department of Stem Cells and Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China.
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun;26(3):637-641. doi: 10.7534/j.issn.1009-2137.2018.03.001.
Current dogma suggests that hematopoietic stem cells (HSC) reside in the top of the hematopoietic hierarchy, which can provide all kinds of mature blood cells constantly through self-renewal and multilineage differentiation potential. HSC has been regarded as the main cell population that maintains the stable hematopoiesis and several differentiation and development patterns of HSC have been summarized based on transplantation results. However, in deed the transplantation experiment is based on an extremely situation of stress which could not really reflect the function of HSC in normal homeostatic condition. Recent studies show that hematopoietic progenitor cells (HPC) play the most important role in hematopoiesis based on different experimental strategies. This article focuses on the controversial subject of the function of HSC and HPC under homostasis.
当前的理论认为，造血干细胞（HSC）处于造血层级的顶端，它能够通过自我更新和多谱系分化潜能持续产生各类成熟血细胞。造血干细胞一直被视为维持稳定造血的主要细胞群体，基于移植结果总结出了造血干细胞的几种分化和发育模式。然而，实际上移植实验是基于一种极端的应激情况，无法真正反映造血干细胞在正常稳态条件下的功能。最近的研究表明，基于不同的实验策略，造血祖细胞（HPC）在造血过程中发挥着最重要的作用。本文聚焦于稳态条件下造血干细胞和造血祖细胞功能这一有争议的主题。
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