Izquierdo I, McGaugh J L
Eur J Pharmacol. 1985 Jul 11;113(1):105-8. doi: 10.1016/0014-2999(85)90348-6.
Mice were trained in a 1-trial inhibitory avoidance task (0.7 mA FS) and tested for retention at 1, 3, or 6 h following training. Posttraining beta-endorphin (0.1 micrograms/mouse i.p.) administration impaired retention at 6 h, but not 1 or 3 h after training. Propranolol (0.3 mg/mouse i.p.), but not naloxone (0.1 mg/mouse i.p.) administered prior to retention testing at 1 or 3 h accelerated the onset of amnesia in mice given posttraining beta-endorphin. Neither propranolol nor naloxone affected retention when given alone. These findings suggest that the delayed onset of the amnesia produced by posttraining beta-endorphin is due to the activation of a beta-adrenergic system.
小鼠接受单次抑制性回避任务训练（0.7毫安足电刺激），并在训练后1、3或6小时进行记忆保持测试。训练后腹腔注射β-内啡肽（0.1微克/只小鼠）会损害6小时后的记忆保持，但不会影响训练后1小时或3小时的记忆保持。在1小时或3小时的记忆保持测试前腹腔注射普萘洛尔（0.3毫克/只小鼠），而非纳洛酮（0.1毫克/只小鼠），可加速训练后给予β-内啡肽的小鼠失忆的发生。单独给予普萘洛尔或纳洛酮均不影响记忆保持。这些发现表明，训练后β-内啡肽导致的失忆延迟发生是由于β-肾上腺素能系统的激活。
