Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA.
Nat Rev Urol. 2018 Sep;15(9):574-584. doi: 10.1038/s41585-018-0040-y.
Invasive squamous cell carcinoma (SCC) of the penis is almost always treated with surgical therapy at the primary site. However, almost all other SCC primary sites, such as anal, vulvar, uterine cervix, head and neck, and oesophagus, and their involved nodal basins, can be successfully treated with radiotherapy or combined chemotherapy and radiation, reserving surgery as a salvage option. Review of the penile cancer literature and examination of data from more common SCC primary sites make a case for complete organ preservation of the penis using definitive combined chemotherapy and radiation, reserving surgical therapies as salvage options.
阴茎浸润性鳞状细胞癌 (SCC) 几乎总是在原发部位采用手术治疗。然而，几乎所有其他 SCC 原发部位，如肛门、外阴、子宫颈、头颈部和食管，以及其受累的淋巴结区域，都可以通过放疗或联合化疗和放疗成功治疗，保留手术作为挽救性选择。对阴茎癌文献的回顾和对更常见 SCC 原发部位数据的检查表明，使用确定性联合化疗和放疗完全保留阴茎器官，将手术治疗作为挽救性选择是合理的。
