甲状腺功能亢进大鼠棕色脂肪组织中肾上腺素能受体密度的变化。
Changes in adrenoreceptor density in brown adipose tissue from hyperthyroid rats.
作者信息
Rothwell N J, Stock M J, Sudera D K
出版信息
Eur J Pharmacol. 1985 Aug 15;114(2):227-9. doi: 10.1016/0014-2999(85)90632-6.
Treatment of rats with triiodothyronine (T3 10 micrograms/100 g per day, 20 days) increased the mass of brown adipose tissue (BAT) and heart ventricle and stimulated beta-adrenoreceptor number (assessed from radioligand binding) by 43% in isolated BAT and heart membranes. alpha-Receptor number was slightly increased in BAT membranes (42%) but reduced in heart from T3-treated rats. The ratio of alpha-receptors/beta-receptors was unaffected by T3 treatment in BAT membranes (control and hyperthyroid = 1.54) but reduced in heart (control = 2.8, T3 = 1.04).
用三碘甲状腺原氨酸治疗大鼠（每天10微克/100克，持续20天），增加了棕色脂肪组织（BAT）和心室的质量，并使分离的BAT和心脏膜中的β-肾上腺素能受体数量（通过放射性配体结合评估）增加了43%。BAT膜中的α-受体数量略有增加（42%），但T3处理的大鼠心脏中的α-受体数量减少。BAT膜中α-受体与β-受体的比例不受T3处理的影响（对照和甲状腺功能亢进组=1.54），但在心脏中降低（对照组=2.8，T3组=1.04）。
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