Carr Brian I, Akkiz Hikmet, Guerra Vito, Üsküdar Oguz, Kuran Sedef, Karaoğullarından Ümit, Tokmak Salih, Ballı Tuğsan, Ülkü Abdulalh, Akçam Tolga, Delik Anıl, Arslan Burcu, Doran Figen, Yalçın Kendal, Altntaş Engin, Özakyol Ayşegül, Yücesoy Mehmet, Bahçeci Halil İbrahim, Polat Kamil Yalçın, Ekinci Nazım, Şimşek Halis, Örmeci Necat, Sonsuz Abdulalh, Demir Mehmet, Kılıç Murat, Uygun Ahmet, Demir Ali, Yilmaz Sezai, Tokat Yaman
Izmir Biomedicine and Genome Institute, Dokuz Eylul University, Izmir, Turkey, and Liver Transplant Institute, Inonu University, Malatya, Turkey
Çukurova University Gastroenterology Department, Adana, Turkey.
Clin Pract (Lond). 2018;15(Spec Issue):625-634. doi: 10.4172/clinical-practice.1000409.
C-reactive protein (CRP) is a blood marker for inflammation and is an independent prognostic factor for many human cancers. Combined with albumin levels, it forms the basis of the Glasgow Index for cancer prognosis. We reviewed the literature on CRP and HCC and also evaluated blood CRP levels and combination CRP plus albumin levels in a large HCC cohort. In order to understand the prognostic significance of CRP, we retrospectively examined a large HCC cohort and examined the relationship of CRP levels to tumor parameters. We report, that CRP alone and CRP plus albumin combined as well, significantly correlated with parameters of HCC aggressiveness, such as maximum tumor dimension (MTD), portal vein thrombosis (PVT) and blood alpha-fetoprotein (AFP) levels, both as individual parameters and all parameters together (Aggressiveness Index). This extends current thinking, to suggest a possible explanation for the usefulness of blood CRP levels in HCC prognostication.
C反应蛋白（CRP）是一种炎症的血液标志物，也是许多人类癌症的独立预后因素。它与白蛋白水平相结合，构成了癌症预后格拉斯哥指数的基础。我们回顾了关于CRP与肝癌的文献，并在一个大型肝癌队列中评估了血液CRP水平以及CRP加白蛋白的联合水平。为了了解CRP的预后意义，我们回顾性研究了一个大型肝癌队列，并研究了CRP水平与肿瘤参数之间的关系。我们报告称，单独的CRP以及CRP加白蛋白的联合指标，均与肝癌侵袭性参数显著相关，如最大肿瘤直径（MTD）、门静脉血栓形成（PVT）和血液甲胎蛋白（AFP）水平，无论是作为单个参数还是所有参数一起（侵袭性指数）。这拓展了当前的认识，为血液CRP水平在肝癌预后评估中的作用提供了一种可能的解释。
