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软组织肉瘤切除术后伸肌机制的同种异体移植重建

Allograft Reconstruction of the Extensor Mechanism after Resection of Soft Tissue Sarcoma.

作者信息

Müller Daniel A, Beltrami Giovanni, Scoccianti Guido, Cuomo Pierluigi, Totti Francesca, Capanna Rodolfo

机构信息

Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, 8008 Zürich, Switzerland.

Department of Orthopedic Oncology, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Firenze, Italy.

出版信息

Adv Orthop. 2018 May 22;2018:6275861. doi: 10.1155/2018/6275861. eCollection 2018.

Abstract

INTRODUCTION

Soft tissue tumors around the knee joint still pose problems for the excision and subsequent reconstruction.

METHODS

In the 6 included patients the soft tissue sarcoma has its base on the anterior surface of the extensor mechanism and expands towards the skin. The entire extensor apparatus (quadriceps tendon, patella, and patellar tendon) was resected and replaced by a fresh-frozen allograft.

RESULTS

The mean follow-up was 6.7 years (range: 2-12.4 years). In two patients a local recurrence occurred, resulting in a 5-year local recurrence-free rate of 66.7% (95% CI: 19.5%-90.4%). Distant metastases were found in 4 patients resulting in a 5-year metastasis-free rate of 33.3% (95% CI: 4.6%-67.5%). Two patients underwent at least one revision surgery, including one patient in whom the allograft had to be removed. According to the ISOLS function score 24.7 points (range: 19-28 points) were achieved at the last follow-up. The mean active flexion of the knee joint was 82.5° (range: 25-120°) and a mean extension lag of 10° (range: 0-30°) was observed.

CONCLUSIONS

The replacement of the extensor mechanism by an allograft is a reasonable option, allowing wide margins and restoration of active extension in most patients.

TRIAL REGISTRATION

The presented study is listed on the ISRCTN registry with trial number ISRCTN63060594.

摘要

引言

膝关节周围的软组织肿瘤在切除及后续重建方面仍存在问题。

方法

在纳入的6例患者中,软组织肉瘤起源于伸肌装置的前表面并向皮肤扩展。切除整个伸肌装置(股四头肌肌腱、髌骨和髌腱),并用新鲜冷冻同种异体移植物进行置换。

结果

平均随访6.7年(范围:2 - 12.4年)。2例患者出现局部复发,5年局部无复发生存率为66.7%(95%可信区间:19.5% - 90.4%)。4例患者发生远处转移,5年无转移生存率为33.3%(95%可信区间:4.6% - 67.5%)。2例患者至少接受了一次翻修手术,其中1例患者的同种异体移植物必须移除。根据ISOLS功能评分,末次随访时得分为24.7分(范围:19 - 28分)。膝关节平均主动屈曲度为82.5°(范围:25 - 120°),平均伸直滞后10°(范围:0 - 30°)。

结论

用同种异体移植物置换伸肌装置是一种合理的选择,能实现广泛切缘并使大多数患者恢复主动伸直功能。

试验注册

本研究已在ISRCTN注册中心登记,试验编号为ISRCTN63060594。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b24/5987318/4a8f256db422/AORTH2018-6275861.001.jpg

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