Darwin Evan, Deshpande Amar, Lev-Tov Hadar
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL.
Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.
ACG Case Rep J. 2018 Jun 20;5:e47. doi: 10.14309/crj.2018.47. eCollection 2018.
Crohn's disease is difficult to manage and often requires multiple medications. While these drugs vastly improve quality of life, physicians must monitor for adverse events. We report a case of a flare of inverse psoriasis after 15 months of treatment with ustekinumab. This is the third reported case of a flare of drug-induced psoriasis with ustekinumab, and it is the first reported case with an inverse presentation; however, the clinical picture is confounded by concomitant use of hydroxychloroquine. Inverse psoriasis is a rare variant of drug-induced psoriasis of which physicians must be cognizant while treating patients with Crohn's disease.
克罗恩病难以控制，通常需要多种药物治疗。虽然这些药物能极大地改善生活质量，但医生必须监测不良事件。我们报告一例在用优特克单抗治疗15个月后出现反向性银屑病发作的病例。这是第三例报道的优特克单抗诱发银屑病发作的病例，也是首例报道的反向性表现病例；然而，临床情况因同时使用羟氯喹而变得复杂。反向性银屑病是药物性银屑病的一种罕见变体，医生在治疗克罗恩病患者时必须对此有所认识。
