英夫利昔单抗诱发克罗恩病患者无菌性脑膜炎
Infliximab-Induced Aseptic Meningitis in a Patient with Crohn's Disease.
作者信息
Junga Zachary, Theeler Brett, Singla Manish
机构信息
Gastroenterology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD.
Neurology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD.
出版信息
ACG Case Rep J. 2018 Jun 20;5:e48. doi: 10.14309/crj.2018.48. eCollection 2018.
Infliximab is an anti-tumor necrosis factor α (TNFα) monoclonal antibody that treats moderate-to-severe Crohn's disease. In rare cases, infliximab has been associated with drug-induced aseptic meningitis. We present a 46-year-old woman with migraines and inflammatory Crohn's colitis treated with intravenous infliximab and methotrexate. She developed nuchal rigidity, photophobia, and headache 2 days after each of her infliximab infusions, with symptom resolution 1 week post-infusion. Her exam, imaging, and cerebrospinal fluid analysis were consistent with drug-induced aseptic meningitis. She discontinued infliximab and started vedolizumab with continued remission of her Crohn's disease.
英夫利昔单抗是一种治疗中度至重度克罗恩病的抗肿瘤坏死因子α（TNFα）单克隆抗体。在罕见情况下，英夫利昔单抗与药物性无菌性脑膜炎有关。我们报告一名46岁患有偏头痛和炎症性克罗恩结肠炎的女性，接受静脉注射英夫利昔单抗和甲氨蝶呤治疗。她在每次英夫利昔单抗输注后2天出现颈部僵硬、畏光和头痛，输注后1周症状缓解。她的检查、影像学和脑脊液分析与药物性无菌性脑膜炎一致。她停用了英夫利昔单抗，开始使用维多珠单抗，克罗恩病持续缓解。
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