Sulakhe P V, Phan N T, Jagadeesh G
Gen Pharmacol. 1985;16(4):311-20. doi: 10.1016/0306-3623(85)90189-2.
Adenylate cyclase activities and the effects of isoproterenol (a beta-adrenergic receptor agonist), carbachol (a cholinergic receptor agonist) and forskolin (a plant diterpene) were determined in homogenates and washed particulate fractions prepared from rat and guinea-pig hearts. Many interesting differences were noted in the stimulatory and inhibitory effects of isoproterenol and carbachol respectively on the heart enzyme. The likely significance of these results is presented.
在从大鼠和豚鼠心脏制备的匀浆及洗涤过的微粒部分中，测定了腺苷酸环化酶活性以及异丙肾上腺素（一种β - 肾上腺素能受体激动剂）、卡巴胆碱（一种胆碱能受体激动剂）和福斯高林（一种植物二萜）的作用。分别观察到异丙肾上腺素和卡巴胆碱对心脏酶的刺激和抑制作用存在许多有趣的差异。本文还阐述了这些结果可能具有的意义。
