1 Deakin University, IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Geelong, VIC, Australia.
2 Centre for Youth Mental Health, Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, VIC, Australia.
Aust N Z J Psychiatry. 2018 Nov;52(11):1026-1029. doi: 10.1177/0004867418783567. Epub 2018 Jun 28.
There is an urgent need for rapidly acting antidepressants. Current therapies share a delayed onset of action, contrasting with drugs of abuse that have rapid psychotropic effects but cause tolerance and dependence. A key uncertainty is whether there is a finite speed limit imposed by the critical role of homeostatic adaptive mechanisms that underpin the efficacy and onset of available psychotropic agents and whether this is mutable with emerging agents with potential rapid onset, in particular ketamine.
目前非常需要起效迅速的抗抑郁药物。现有的治疗方法都存在起效延迟的问题，这与滥用药物形成鲜明对比，后者具有快速的精神作用，但会导致耐受和依赖。一个关键的不确定性因素是，是否存在由稳态适应机制的关键作用所施加的有限速度限制，这种机制是现有精神药物的疗效和起效的基础，以及这种限制是否可以随着具有潜在快速起效的新型药物（特别是氯胺酮）的出现而改变。
