Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai 200444, China.
Department of Pharmacology and Toxicology and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, 46202, United States.
CNS Neurol Disord Drug Targets. 2019;18(4):273-278. doi: 10.2174/1871527317666180627114849.
Objective & Background: Voltage-gated sodium channels (VGSCs) and potassium channels are critical in the generation of action potentials in the nervous system. VGSCs and potassium channels play important roles in the five fundamental senses of vision, audition, olfaction, taste and touch. Dysfunctional VGSCs are associated with clinical sensory symptoms, such as hyperpselaphesia, parosphresia, and so on. Conclusion: This short review highlights the recent advances in the study of VGSCs in sensory information processing and discusses the potential role of VGSCs to serve as pharmacological targets for the treatment of sensory system diseases.
电压门控钠离子通道（VGSCs）和钾通道在神经系统产生动作电位中至关重要。VGSCs 和钾通道在视觉、听觉、嗅觉、味觉和触觉这五种基本感觉中发挥着重要作用。功能失调的 VGSCs 与临床感觉症状有关，如 Hyperpselaphesia、Parosphresia 等。结论：本综述重点介绍了 VGSCs 在感觉信息处理研究方面的最新进展，并讨论了 VGSCs 作为治疗感觉系统疾病的药理学靶点的潜力。
