支气管扩张症患者仅行肺康复治疗与肺康复联合营养补充治疗的随机对照研究。
Pulmonary Rehabilitation Only Versus With Nutritional Supplementation in Patients With Bronchiectasis: A RANDOMIZED CONTROLLED TRIAL.
机构信息
Neumología, Hospital de Alta Resolución de Benalmádena, Málaga, Spain (Dr Doña); Pneumology, Málaga Regional University Hospital, Instituto de Biomedicina de Málaga, Málaga University, Spain (Dr C. Olveira); Hospital Regional Universitario de Málaga, Málaga, Spain (Mr Palenque and Drs Dorado, Godoy, and Espildora); UGC Endocrinología y Nutrición, Instituto de Biomedicina de Málaga, Málaga University, Spain (Ms Porras); Lecture University of Cádiz, and Department of Physiotherapy, Faculty of Nursing and Physiotherapy, University of Cadiz, Spain (Dr Martín-Valero); and UGC de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga, Instituto de Biomedicina de Málaga, Málaga University, Spain (Dr G. Olveira).
出版信息
J Cardiopulm Rehabil Prev. 2018 Nov;38(6):411-418. doi: 10.1097/HCR.0000000000000341.
PURPOSE
Pulmonary rehabilitation (PR) is recommended for bronchiectasis, but there is little evidence of its efficacy in these patients. The aim of this study was to assess the effect of PR in normally nourished patients with noncystic fibrosis bronchiectasis compared with the effect of PR plus an oral nutritional supplement (PRONS).
METHODS
A single-center randomized controlled trial, parallel treatment design in which participants were randomly assigned to receive PR for 12 wk or PR plus a high-protein nutritional supplement enriched with beta-hydroxy-beta-methylbutyrate. Outcome assessments were performed at baseline, 12 and 24 wk including cardiopulmonary exercise testing, health-related quality of life (HRQOL), bronchorrhea, dyspnea, psychological symptoms, spirometry, and exacerbations.
RESULTS
Thirty patients were randomized into 2 groups of 15 participants. In both groups, cardiopulmonary exercise testing, HRQOL, dyspnea, and spirometry parameters significantly increased from baseline at 3 and/or 6 mo.
CONCLUSION
PR improved exercise capacity, HRQOL, and respiratory parameters. The use of PRONS did not have a significant effect on the results.
目的
肺康复（PR）被推荐用于支气管扩张症，但针对其在这些患者中的疗效证据较少。本研究旨在评估与 PR 加口服营养补充剂（PRONS）相比，PR 对非囊性纤维化支气管扩张症且营养状况正常的患者的疗效。
方法
这是一项单中心随机对照试验，采用平行治疗设计，参与者被随机分配接受 12 周的 PR 或 PR 加富含β-羟基-β-甲基丁酸的高蛋白营养补充剂。在基线、12 周和 24 周进行包括心肺运动测试、健康相关生活质量（HRQOL）、支气管分泌物、呼吸困难、心理症状、肺量测定和恶化情况在内的评估。
结果
30 名患者被随机分为两组，每组 15 名参与者。两组患者的心肺运动测试、HRQOL、呼吸困难和肺量测定参数均从基线开始在 3 个月和/或 6 个月时显著改善。
结论
PR 改善了运动能力、HRQOL 和呼吸参数。使用 PRONS 对结果没有显著影响。
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