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由暗褐链霉菌产生的血管紧张素转化酶抑制剂。发现、分类及发酵

Angiotensin converting enzyme inhibitors produced by Streptomyces chromofuscus. Discovery, taxonomy and fermentation.

作者信息

Nakatsukasa W M, Wilgus R M, Thomas D N, Mertz F P, Boeck L D

出版信息

J Antibiot (Tokyo). 1985 Aug;38(8):997-1002. doi: 10.7164/antibiotics.38.997.

DOI:10.7164/antibiotics.38.997
PMID:2995296
Abstract

Culture A58365.1, NRRL 15098, identified as a new strain of Streptomyces chromofuscus, was found to produce two novel angiotensin converting enzyme (ACE) inhibitors, A58365A and A58365B. Fermentation medium studies afforded an increase in ACE inhibitor titers from less than 1 microgram/ml to greater than 20 micrograms/ml. Proline was the obligatory supplement for ACE inhibitor biosynthesis.

摘要

菌株A58365.1，保藏编号NRRL 15098，被鉴定为暗褐链霉菌的一个新菌株，它能产生两种新型血管紧张素转换酶（ACE）抑制剂，即A58365A和A58365B。发酵培养基研究使ACE抑制剂效价从低于1微克/毫升提高到高于20微克/毫升。脯氨酸是ACE抑制剂生物合成的必需补充物。

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