盘基网柄菌细胞外及膜结合磷酸二酯酶的叶酸及叶酸类似物诱导作用
Induction by folate and folate analogs of extracellular and membrane-bound phosphodiesterase from Dictyostelium discoideum.
作者信息
van Ophem P, van Driel R
出版信息
J Bacteriol. 1985 Oct;164(1):143-6. doi: 10.1128/jb.164.1.143-146.1985.
Abstract
Folate stimulation is known to enhance Dictyostelium discoideum differentiation. During early differentiation, D. discoideum cells possess two classes of folate receptors which can be distinguished by their difference in specificity (R. J. W. de Wit, FEBS Lett. 150, 445-448, 1982). We investigated the type of receptor by which folate affects cell differentiation. Two independently regulated developmental markers were used: the extracellular phosphodiesterase-inhibitor system and cell-surface phosphodiesterase activity. Our results indicate that the major effect of folate on development is mediated by the folate-specific receptor. The nonspecific folate receptor was only involved in a minor, transient enhancement of the extracellular phosphodiesterase activity very early in development.
摘要
已知叶酸刺激可增强盘基网柄菌的分化。在早期分化过程中，盘基网柄菌细胞拥有两类叶酸受体，可根据其特异性差异加以区分（R. J. W. 德维特，《欧洲生物化学学会联合会快报》150，445 - 448，1982）。我们研究了叶酸通过何种受体影响细胞分化。使用了两个独立调控的发育标志物：细胞外磷酸二酯酶抑制系统和细胞表面磷酸二酯酶活性。我们的结果表明，叶酸对发育的主要影响是由叶酸特异性受体介导的。非特异性叶酸受体仅在发育非常早期对细胞外磷酸二酯酶活性有轻微的、短暂的增强作用。
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Binding of the chemoattractant folic acid by Dictyostelium discoideum cells.
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