a Department of Biological Sciences , Bridgewater State University , Bridgewater , MA , USA.
Chronobiol Int. 2018 Sep;35(10):1456-1463. doi: 10.1080/07420528.2018.1488259. Epub 2018 Jun 28.
Disruptions to the circadian rhythm can lead to altered metabolism. Modification of thyroid function may be a reason why circadian misalignment may contribute to future metabolic disorders. We investigated whether circadian disruption through constant light (LL) can lead to variations in hormone levels associated with thyroid function. Mice were exposed to LL or a 12:12 Light:Dark (LD) cycle for 6 weeks; then glucose tolerance and thyroid hormone levels were measured at ZT 6 and ZT 18. There was day/night variation in glucose tolerance, but LL had no effect. LL reduced TSH, increased fT4, and abolished day/night variation in fT3 and leptin. These findings illustrate that LL alters thyroid-related hormones, providing evidence of a link between circadian disruption and thyroid function.
昼夜节律紊乱可导致代谢改变。甲状腺功能的改变可能是昼夜节律失调导致未来代谢紊乱的原因之一。我们研究了通过持续光照（LL）破坏昼夜节律是否会导致与甲状腺功能相关的激素水平发生变化。将小鼠暴露于 LL 或 12:12 光照：黑暗（LD）周期中 6 周；然后在 ZT6 和 ZT18 测量葡萄糖耐量和甲状腺激素水平。葡萄糖耐量存在昼夜变化，但 LL 没有影响。LL 降低了 TSH，增加了游离 T4，并消除了游离 T3 和瘦素的昼夜变化。这些发现表明，LL 改变了与甲状腺相关的激素，为昼夜节律紊乱与甲状腺功能之间的联系提供了证据。
