Seber S, Turkmen E, Harputoğlu H, Yeşil H, Arpacι E, Menekşe S, Pilancι K, Oruç Z, Taskoylu B Y, Gumusay O, Aksoy A, Karaagac M, Ozarslan E, Yetisyigit T
Eur J Gynaecol Oncol. 2017;38(2):227-231.
Central nervous system (CNS) metastasis is a rare event in the course of late stage epithelial ovarian cancer (EOC); however its incidence is increasing in parallel with prolonged survival of patients.
The authors assessed the clinical parameters and potential prognostic features in patients with CNS metastatic disease.
Clinical data of the 33 patients from the participating centers were retrospectively collected and analyzed. Median age at the time of CNS metastasis was 57 years. Median time from the diagnosis of primary EOC until CNS metastatic disease was 22 months. Nearly half (45.5%) of the patients had single CNS metastatic lesions and all patients in the study group except two received radiotherapy as palliative treatment. Median overall survival (OS) from the time of CNS metastasis was 15 months (0-66). At univariate analysis only number of brain metastatic lesions (p = 0.001) and presence of extracranial disease (p = 0.004) were strongly associated with OS whereas multimodal treatment, size of metastatic lesions, platinum sensitivity, age, grade, and disease stage at presentation were not. Development of CNS metastasis carries a poor prognosis, however patients with single metastatic lesions and only intracranial metastatic disease can have prolonged survival after appropriate palliative management of their disease.
中枢神经系统（CNS）转移是晚期上皮性卵巢癌（EOC）病程中的罕见事件；然而，其发生率随着患者生存期的延长而增加。
作者评估了中枢神经系统转移性疾病患者的临床参数和潜在的预后特征。
回顾性收集并分析了参与研究中心的33例患者的临床资料。中枢神经系统转移时的中位年龄为57岁。从原发性EOC诊断到中枢神经系统转移性疾病的中位时间为22个月。近一半（45.5%）的患者有单个中枢神经系统转移病灶，研究组中除两名患者外，所有患者均接受了姑息性放疗。从中枢神经系统转移时起的中位总生存期（OS）为15个月（0 - 66个月）。单因素分析显示，仅脑转移病灶数量（p = 0.001）和颅外疾病的存在（p = 0.004）与总生存期密切相关，而多模式治疗、转移病灶大小、铂敏感性、年龄、分级和就诊时疾病分期则不然。中枢神经系统转移的发生预后较差，然而，有单个转移病灶且仅存在颅内转移性疾病的患者在对其疾病进行适当的姑息治疗后可延长生存期。
