Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of alterations and high mutation load.
作者信息
Vosberg Sebastian, Hartmann Luise, Metzeler Klaus H, Konstandin Nikola P, Schneider Stephanie, Varadharajan Ashok, Hauser Andreas, Krebs Stefan, Blum Helmut, Bohlander Stefan K, Hiddemann Wolfgang, Tischer Johanna, Spiekermann Karsten, Greif Philipp A
机构信息
Experimental Leukemia and Lymphoma Research, Department of Medicine III, University Hospital, LMU Munich, Germany.
German Cancer Consortium (DKTK), partner site Munich, Germany.
出版信息
Haematologica. 2018 Dec;103(12):e581-e584. doi: 10.3324/haematol.2018.193102. Epub 2018 Jun 28.
Abstract
摘要
相似文献
1
Relapse of acute myeloid leukemia after allogeneic stem cell transplantation is associated with gain of alterations and high mutation load.异基因干细胞移植后急性髓系白血病的复发与改变的获得和高突变负荷相关。
Haematologica. 2018 Dec;103(12):e581-e584. doi: 10.3324/haematol.2018.193102. Epub 2018 Jun 28.
2
Wilms' tumor gene 1 is an independent prognostic factor for pediatric acute myeloid leukemia following allogeneic hematopoietic stem cell transplantation.Wilms' 肿瘤基因 1 是异基因造血干细胞移植后儿童急性髓系白血病的独立预后因素。
BMC Cancer. 2021 Mar 19;21(1):292. doi: 10.1186/s12885-021-08022-0.
3
The usefulness of monitoring WT1 gene transcripts for the prediction and management of relapse following allogeneic stem cell transplantation in acute type leukemia.监测WT1基因转录本在急性白血病异基因干细胞移植后复发预测及管理中的作用。
Blood. 2003 Mar 1;101(5):1698-704. doi: 10.1182/blood-2002-06-1831. Epub 2002 Oct 24.
4
Low WT1 transcript levels at diagnosis predicted poor outcomes of acute myeloid leukemia patients with t(8;21) who received chemotherapy or allogeneic hematopoietic stem cell transplantation.诊断时WT1转录水平低预示着接受化疗或异基因造血干细胞移植的t(8;21)急性髓系白血病患者预后不良。
Chin J Cancer. 2016 May 19;35:46. doi: 10.1186/s40880-016-0110-6.
5
Different recovery patterns of CMV-specific and WT1-specific T cells in patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation: Impact of CMV infection and leukemia relapse.异基因造血细胞移植后急性髓系白血病患者 CMV 特异性和 WT1 特异性 T 细胞的不同恢复模式：CMV 感染和白血病复发的影响。
Front Immunol. 2023 Feb 7;13:1027593. doi: 10.3389/fimmu.2022.1027593. eCollection 2022.
6
Wilms Tumor 1 Expression and Pre-emptive Immunotherapy in Patients with Acute Myeloid Leukemia Undergoing an Allogeneic Hemopoietic Stem Cell Transplantation.肾母细胞瘤1在接受异基因造血干细胞移植的急性髓系白血病患者中的表达及预防性免疫治疗
Biol Blood Marrow Transplant. 2016 Jul;22(7):1242-1246. doi: 10.1016/j.bbmt.2016.03.005. Epub 2016 Mar 10.
7
WT1 Measurable Residual Disease Assay in Patients With Acute Myeloid Leukemia Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation: Optimal Time Points, Thresholds, and Candidates.WT1 可测量残留病检测在接受异基因造血干细胞移植的急性髓系白血病患者中的应用：最佳时间点、阈值和候选者。
Biol Blood Marrow Transplant. 2019 Oct;25(10):1925-1932. doi: 10.1016/j.bbmt.2019.05.033. Epub 2019 Jun 4.
8
Efficacy of geneguided preemptive therapy for prevention of relapse in acute myeloid leukemia after transplantation and its optimal intervention threshold.基因引导的抢先治疗对预防急性髓系白血病移植后复发的疗效及其最佳干预阈值
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2024 Jul 28;49(7):1120-1129. doi: 10.11817/j.issn.1672-7347.2024.240351.
9
Wilms' tumor gene 1 transcript levels in leukapheresis of peripheral blood hematopoietic cells predict relapse risk in patients autografted for acute myeloid leukemia.外周血造血细胞白细胞分离术中肾母细胞瘤基因1转录水平可预测急性髓系白血病自体移植患者的复发风险。
Biol Blood Marrow Transplant. 2014 Oct;20(10):1586-91. doi: 10.1016/j.bbmt.2014.06.017. Epub 2014 Jun 18.
10
WT1-guided pre-emptive therapy after allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia.WT1 指导的异基因造血干细胞移植后急性髓系白血病的抢先治疗。
Int J Hematol. 2024 Sep;120(3):337-346. doi: 10.1007/s12185-024-03795-z. Epub 2024 May 25.
引用本文的文献
1
Biology of post-transplant relapse: actionable features.移植后复发的生物学：可采取行动的特征。
Hematology Am Soc Hematol Educ Program. 2024 Dec 6;2024(1):736-743. doi: 10.1182/hematology.2024000588.
2
Recurrent DDX41 mutation in very late relapse after allogeneic stem cell transplantation.异基因干细胞移植后极晚期复发中DDX41基因的复发性突变
Leukemia. 2024 Mar;38(3):667-670. doi: 10.1038/s41375-024-02152-7. Epub 2024 Jan 18.
3
Genetic features and outcomes of allogeneic transplantation in patients with WT1-mutated myeloid neoplasms.WT1 突变型髓系肿瘤患者异基因移植的遗传特征及预后
Blood Adv. 2024 Feb 13;8(3):562-570. doi: 10.1182/bloodadvances.2023010960.
4
Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin.米哚妥林治疗下伴 FLT3-ITD 突变的急性髓系白血病的克隆进化。
Blood. 2021 Jun 3;137(22):3093-3104. doi: 10.1182/blood.2020007626.
5
Biology of Disease Relapse in Myeloid Disease: Implication for Strategies to Prevent and Treat Disease Relapse After Stem-Cell Transplantation.髓系疾病中疾病复发的生物学：对干细胞移植后预防和治疗疾病复发策略的启示
J Clin Oncol. 2021 Feb 10;39(5):386-396. doi: 10.1200/JCO.20.01587. Epub 2021 Jan 12.
6
Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status.从 TET 不足状态进展为髓性白血病的分子发病机制。
Blood Adv. 2020 Mar 10;4(5):845-854. doi: 10.1182/bloodadvances.2019001324.
7
CD123 as a Therapeutic Target in the Treatment of Hematological Malignancies.CD123作为血液系统恶性肿瘤治疗的一个治疗靶点。
Cancers (Basel). 2019 Sep 12;11(9):1358. doi: 10.3390/cancers11091358.
8
Clonal evolution of acute myeloid leukemia from diagnosis to relapse.从诊断到复发的急性髓系白血病的克隆进化。
Genes Chromosomes Cancer. 2019 Dec;58(12):839-849. doi: 10.1002/gcc.22806. Epub 2019 Sep 3.
9
Uncovering the Genomic Landscape in Newly Diagnosed and Relapsed Pediatric Cytogenetically Normal FLT3-ITD AML.揭示新诊断和复发的儿童细胞遗传学正常 FLT3-ITD AML 中的基因组特征。
Clin Transl Sci. 2019 Nov;12(6):641-647. doi: 10.1111/cts.12669. Epub 2019 Aug 20.
本文引用的文献
1
Concomitant mutations predict poor prognosis in acute myeloid leukemia patients with double mutant .伴随突变预示着具有双突变的急性髓系白血病患者预后不良。
Haematologica. 2018 Nov;103(11):e510-e513. doi: 10.3324/haematol.2018.189043. Epub 2018 May 17.
2
Evolution of Cytogenetically Normal Acute Myeloid Leukemia During Therapy and Relapse: An Exome Sequencing Study of 50 Patients.治疗和复发期间细胞遗传学正常急性髓系白血病的演变：50 例患者的外显子组测序研究。
Clin Cancer Res. 2018 Apr 1;24(7):1716-1726. doi: 10.1158/1078-0432.CCR-17-2344. Epub 2018 Jan 12.
3
Mutational analysis of disease relapse in patients allografted for acute myeloid leukemia.急性髓系白血病异体移植患者疾病复发的突变分析
Blood Adv. 2016 Dec 14;1(3):193-204. doi: 10.1182/bloodadvances.2016000760. eCollection 2016 Dec 27.
4
High prognostic value of pre-allogeneic stem cell transplantation minimal residual disease detection by WT1 gene expression in AML transplanted in cytologic complete remission.WT1基因表达检测在细胞完全缓解后接受异基因干细胞移植的急性髓系白血病患者中对移植前微小残留病检测具有较高的预后价值。
Leuk Res. 2017 Dec;63:22-27. doi: 10.1016/j.leukres.2017.10.010. Epub 2017 Oct 27.
5
Bone Marrow WT1 Levels in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplasia: Clinically Relevant Time Points and 100 Copies Threshold Value.异基因造血干细胞移植治疗急性髓系白血病和骨髓增生异常综合征中的骨髓 WT1 水平：有临床意义的时间点和 100 拷贝阈值。
Biol Blood Marrow Transplant. 2018 Jan;24(1):55-63. doi: 10.1016/j.bbmt.2017.09.001. Epub 2017 Sep 20.
6
Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia.急性髓系白血病驱动基因突变的频谱及预后相关性。
Blood. 2016 Aug 4;128(5):686-98. doi: 10.1182/blood-2016-01-693879. Epub 2016 Jun 10.
7
Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor.T细胞活化的先驱者：由NAADP和1型兰尼碱受体介导的初始局部Ca2+信号
Sci Signal. 2015 Oct 13;8(398):ra102. doi: 10.1126/scisignal.aab0863.
8
WT1 mutations are secondary events in AML, show varying frequencies and impact on prognosis between genetic subgroups.WT1 突变是 AML 的继发事件，在不同的遗传亚组中具有不同的频率，并对预后产生影响。
Leukemia. 2015 Mar;29(3):660-7. doi: 10.1038/leu.2014.243. Epub 2014 Aug 11.
9
Isolated trisomy 13 defines a homogeneous AML subgroup with high frequency of mutations in spliceosome genes and poor prognosis.孤立性 13 三体定义了一个具有高频率剪接体基因突变和不良预后的同质 AML 亚组。
Blood. 2014 Aug 21;124(8):1304-11. doi: 10.1182/blood-2013-12-540716. Epub 2014 Jun 12.
10
Gain of function in the immune system caused by a ryanodine receptor 1 mutation.免疫系统中 Ryanodine 受体 1 突变导致的功能获得。
J Cell Sci. 2013 Aug 1;126(Pt 15):3485-92. doi: 10.1242/jcs.130310. Epub 2013 May 23.
Zotero 插件