Jacobs Terry M, Poehlmann Cathy E, Kiupel Matti
Park Pet Hospital, 7378 N. Teutonia Ave., Milwaukee, WI 53209, USA.
Department of Pathobiology and Diagnostic Investigation, Michigan State University, 4125 Beaumont Road, Room 152A, Lansing, MI 48910, USA.
Case Rep Vet Med. 2017 May 9;2017:6952634. doi: 10.1155/2017/6952634. eCollection 2017.
This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsocervical subcutaneous masses at the injection site three weeks after receiving DAPP-Lepto, Rabies, and Bordetella vaccinations. A high-grade soft tissue sarcoma was diagnosed microscopically and immunohistochemistry revealed positive expression of VEGFr, PDGFr, SCF, and EGFR. Repeat surgical resections and targeted treatment with toceranib resulted in a stable remission for nearly two years.
本病例报告记录了一只狗在多次接种疫苗部位迅速发展为高级别肉瘤的临床和病理结果，并跟踪了手术及托西替尼辅助治疗的反应。一只11岁已绝育的雌性拉布拉多寻回犬在接种犬瘟热、腺病毒、副流感和细小病毒、钩端螺旋体、狂犬病及博德特氏菌疫苗三周后，注射部位出现颈背皮下肿块。显微镜下诊断为高级别软组织肉瘤，免疫组化显示血管内皮生长因子受体（VEGFr）、血小板衍生生长因子受体（PDGFr）、干细胞因子（SCF）和表皮生长因子受体（EGFR）呈阳性表达。重复手术切除及托西替尼靶向治疗使病情稳定缓解近两年。
