Boyle Julia, Clement Cassandra, Atherton Abril, Stock Christopher
Assistant Professor, Idaho State University, Meridian, Idaho; Mental Health Clinical Pharmacist, Boise VA Medical Center, Boise, Idaho,
Outpatient Mental Health Clinical Pharmacy Specialist, Orlando VA Medical Center, Orlando, Florida.
Ment Health Clin. 2018 Mar 23;7(6):276-281. doi: 10.9740/mhc.2017.11.276. eCollection 2017 Nov.
Opioid-related overdoses have risen despite extensive media coverage and apparent awareness of this public health crisis. Emergency department visits related to opioid use nearly tripled from 2004 to 2011. Patients with mental illness are more likely to be prescribed opioids and have higher rates of overdose. This retrospective chart review sought to determine if opioid represcribing occurred after patients were treated for a nonfatal opioid overdose (NFO) at a Veterans Affairs hospital.
Patients who experienced an NFO between 2009 and 2013 were included and charts reviewed until January 1, 2016. Review of the electronic medical record (EMR) was performed to determine if and when opioids were again prescribed after NFO.
Fifty-six veterans met the inclusion criteria. A new opioid prescription was issued to 82% of patients within 3 months following the index NFO date. The average daily morphine equivalent dose prescribed before (122 mg) and after (120 mg) NFO did not differ. A subsequent opioid overdose event occurred in 25% of patients, and there was 1 fatal event. Only 1 patient had medication overdose on the problem list of their EMR.
Despite experiencing NFO, veterans continued to be prescribed opioids without significant changes in the drug or dose; some experienced repeated overdose events, possibly due to poor communication and documentation of NFO. Pharmacists can play a key role in clinical interventions and education of patients and prescribers.
尽管媒体广泛报道且公众明显意识到这场公共卫生危机,但与阿片类药物相关的过量用药事件仍在增加。2004年至2011年期间,与阿片类药物使用相关的急诊科就诊人数几乎增加了两倍。患有精神疾病的患者更有可能被开具阿片类药物处方,且过量用药率更高。这项回顾性病历审查旨在确定在退伍军人事务医院接受非致命性阿片类药物过量(NFO)治疗的患者之后是否会再次开具阿片类药物处方。
纳入2009年至2013年期间经历过NFO的患者,并审查病历直至2016年1月1日。通过审查电子病历(EMR)来确定在NFO之后是否以及何时再次开具阿片类药物处方。
56名退伍军人符合纳入标准。在首次NFO日期后的3个月内,82%的患者获得了新的阿片类药物处方。NFO之前(122毫克)和之后(120毫克)开具的平均每日吗啡当量剂量没有差异。25%的患者随后发生了阿片类药物过量事件,并有1例致命事件。在其EMR的问题列表中,只有1名患者有药物过量记录。
尽管经历了NFO,但退伍军人仍继续被开具阿片类药物处方,药物或剂量没有显著变化;一些人经历了反复的过量事件,可能是由于NFO的沟通和记录不佳。药剂师可以在临床干预以及对患者和开处方者的教育中发挥关键作用。