Weintraub Sandra, Carrillo Maria C, Farias Sarah Tomaszewski, Goldberg Terry E, Hendrix James A, Jaeger Judith, Knopman David S, Langbaum Jessica B, Park Denise C, Ropacki Michael T, Sikkes Sietske A M, Welsh-Bohmer Kathleen A, Bain Lisa J, Brashear Robert, Budur Kumar, Graf Ana, Martenyi Ferenc, Storck Marta Segardahl, Randolph Christopher
Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Alzheimers Dement (N Y). 2018 Feb 13;4:64-75. doi: 10.1016/j.trci.2018.01.003. eCollection 2018.
The Alzheimer's Association's Research Roundtable met in November 2016 to explore how best to measure changes in cognition and function in the preclinical stage of Alzheimer's disease. This review will cover the tools and instruments currently available to identify populations for prevention trials, and measure subtle disease progression in the earliest stages of Alzheimer's disease, and will include discussions of suitable cognitive, behavioral, functional, composite, and biological endpoints for prevention trials. Current prevention trials are reviewed including TOMMOROW, Alzheimer's Prevention Initiative Autosomal Dominant Alzheimer's Disease Trial, the Alzheimer's Prevention Initiative Generation Study, and the Anti-Amyloid Treatment in Asymptomatic Alzheimer's to compare current approaches and tools that are being developed.
阿尔茨海默病协会研究圆桌会议于2016年11月召开，探讨如何最好地测量阿尔茨海默病临床前阶段认知和功能的变化。本综述将涵盖目前可用于识别预防试验人群以及测量阿尔茨海默病最早阶段细微疾病进展的工具和仪器，并将讨论预防试验适用的认知、行为、功能、综合和生物学终点。对当前的预防试验进行了综述，包括“明日（TOMMOROW）试验”、阿尔茨海默病预防倡议常染色体显性遗传阿尔茨海默病试验、阿尔茨海默病预防倡议代际研究以及无症状阿尔茨海默病的抗淀粉样蛋白治疗，以比较目前正在开发的方法和工具。
Zotero 插件