Huijbers Willem, Pinter Nandor K, Spaltman Mandy, Cornelis Mike, Schmand Ben, Alnaji Baraa, Yargeau Maxwell, Harlock Sarah, Dorn Ryu Platinum, Ajtai Bela, Westphal Erica S, van Elswijk Gijs
Philips Research, Eindhoven, Netherlands.
Dent Neurologic Institute, Amherst, NY, United States.
Front Psychol. 2024 Dec 30;15:1451843. doi: 10.3389/fpsyg.2024.1451843. eCollection 2024.
We evaluated a digital cognitive assessment platform, Philips IntelliSpace Cognition, in a case-control study of patients diagnosed with mild cognitive impairment (MCI) and cognitively normal (CN) older adults. Performance on individual neuropsychological tests, cognitive -scores, and Alzheimer's disease (AD)-specific composite scores was compared between the CN and MCI groups. These groups were matched for age, sex, and education. Performance on all but two neuropsychological tests was worse in the MCI group. After ranking the cognitive scores by effect size, we found that the memory score was the most impaired, followed by executive functioning. The Early AD/MCI Alzheimer's Cognitive Composite (EMACC) and Preclinical Alzheimer's Cognitive Composite (PACC) scores were constructed from the digital tests on Philips IntelliSpace Cognition. Both AD-specific composite scores showed greater sensitivity and specificity than the Mini-Mental State Examination or individual cognitive -scores. Together, these results demonstrate the diagnostic value of Philips IntelliSpace Cognition in patients with MCI.
我们在一项针对被诊断为轻度认知障碍（MCI）的患者和认知正常（CN）的老年人的病例对照研究中，评估了一个数字认知评估平台——飞利浦IntelliSpace认知平台。比较了CN组和MCI组在个体神经心理学测试、认知分数以及阿尔茨海默病（AD）特异性综合分数方面的表现。这两组在年龄、性别和教育程度上进行了匹配。除两项神经心理学测试外，MCI组在所有测试中的表现都更差。按效应大小对认知分数进行排序后，我们发现记忆分数受损最严重，其次是执行功能。早期AD/MCI阿尔茨海默病认知综合评分（EMACC）和临床前阿尔茨海默病认知综合评分（PACC）是根据飞利浦IntelliSpace认知平台上的数字测试构建的。这两个AD特异性综合评分均显示出比简易精神状态检查表或个体认知分数更高的敏感性和特异性。总之，这些结果证明了飞利浦IntelliSpace认知平台在MCI患者中的诊断价值。
